Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery: the impact of radiotherapy on second IBTR

Makoto Ishitobi; Yasuhiro Okumura; Reiki Nishimura; Katsuhiko Nakatsukasa; Masahiko Tanabe; Atsushi Yoshida; Norikazu Masuda; Tadahiko Shien; Satoru Tanaka; Yoshifumi Komoike; Nobuyuki Arima; Tetsuya Taguchi; Hideo Inaji

doi:10.1007/s12282-013-0454-6

Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery: the impact of radiotherapy on second IBTR

Makoto Ishitobi, Yasuhiro Okumura, Reiki Nishimura, Katsuhiko Nakatsukasa, Masahiko Tanabe, Atsushi Yoshida, Norikazu Masuda, Tadahiko Shien, Satoru Tanaka, Yoshifumi Komoike, Nobuyuki Arima, Tetsuya Taguchi, Hideo Inaji

University Hospital

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Objectives: There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR). Especially, the impact of radiotherapy (RT) on a second IBTR is unknown.

Methods: We retrospectively analyzed 143 patients from 8 institutions in Japan who underwent repeat lumpectomy after IBTR. The risk factors of a second IBTR were assessed.

Results: The median follow-up period was 4.8 years. The 5-year second IBTR-free survival rate was 80.7 %. There was a significant difference in the second IBTR-free survival rate according to RT (p = 0.0003, log-rank test). The 5-year second IBTR-free survival rates for patients who received RT after initial surgery, RT after salvage surgery, and no RT were 78.0, 93.5, and 52.7 %, respectively. Multivariate analysis revealed that RT was a significantly independent predictive factor of second IBTR-free survival.

Conclusion: Repeat lumpectomy plus RT is a reasonable option in patients who did not undergo RT at the initial surgery. In contrast, caution is needed when RT is omitted in patients who have undergone repeat lumpectomy.

Original language	English
Pages (from-to)	754-760
Number of pages	7
Journal	Breast Cancer
Volume	21
Issue number	6
DOIs	https://doi.org/10.1007/s12282-013-0454-6
Publication status	Published - 2014

Keywords

Breast cancer
Breast-conserving surgery
Ipsilateral breast tumor recurrence
Repeat lumpectomy

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Pharmacology (medical)

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Ishitobi, M., Okumura, Y., Nishimura, R., Nakatsukasa, K., Tanabe, M., Yoshida, A., Masuda, N., Shien, T., Tanaka, S., Komoike, Y., Arima, N., Taguchi, T., & Inaji, H. (2014). Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery: the impact of radiotherapy on second IBTR. Breast Cancer, 21(6), 754-760. https://doi.org/10.1007/s12282-013-0454-6

Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery : the impact of radiotherapy on second IBTR. / Ishitobi, Makoto; Okumura, Yasuhiro; Nishimura, Reiki; Nakatsukasa, Katsuhiko; Tanabe, Masahiko; Yoshida, Atsushi; Masuda, Norikazu; Shien, Tadahiko; Tanaka, Satoru; Komoike, Yoshifumi; Arima, Nobuyuki; Taguchi, Tetsuya; Inaji, Hideo.

In: Breast Cancer, Vol. 21, No. 6, 2014, p. 754-760.

Research output: Contribution to journal › Article › peer-review

Ishitobi, M, Okumura, Y, Nishimura, R, Nakatsukasa, K, Tanabe, M, Yoshida, A, Masuda, N, Shien, T, Tanaka, S, Komoike, Y, Arima, N, Taguchi, T & Inaji, H 2014, 'Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery: the impact of radiotherapy on second IBTR', Breast Cancer, vol. 21, no. 6, pp. 754-760. https://doi.org/10.1007/s12282-013-0454-6

Ishitobi, Makoto ; Okumura, Yasuhiro ; Nishimura, Reiki ; Nakatsukasa, Katsuhiko ; Tanabe, Masahiko ; Yoshida, Atsushi ; Masuda, Norikazu ; Shien, Tadahiko ; Tanaka, Satoru ; Komoike, Yoshifumi ; Arima, Nobuyuki ; Taguchi, Tetsuya ; Inaji, Hideo. / Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery : the impact of radiotherapy on second IBTR. In: Breast Cancer. 2014 ; Vol. 21, No. 6. pp. 754-760.

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abstract = "Objectives: There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR). Especially, the impact of radiotherapy (RT) on a second IBTR is unknown.Methods: We retrospectively analyzed 143 patients from 8 institutions in Japan who underwent repeat lumpectomy after IBTR. The risk factors of a second IBTR were assessed.Results: The median follow-up period was 4.8 years. The 5-year second IBTR-free survival rate was 80.7 %. There was a significant difference in the second IBTR-free survival rate according to RT (p = 0.0003, log-rank test). The 5-year second IBTR-free survival rates for patients who received RT after initial surgery, RT after salvage surgery, and no RT were 78.0, 93.5, and 52.7 %, respectively. Multivariate analysis revealed that RT was a significantly independent predictive factor of second IBTR-free survival.Conclusion: Repeat lumpectomy plus RT is a reasonable option in patients who did not undergo RT at the initial surgery. In contrast, caution is needed when RT is omitted in patients who have undergone repeat lumpectomy.",

keywords = "Breast cancer, Breast-conserving surgery, Ipsilateral breast tumor recurrence, Repeat lumpectomy",

author = "Makoto Ishitobi and Yasuhiro Okumura and Reiki Nishimura and Katsuhiko Nakatsukasa and Masahiko Tanabe and Atsushi Yoshida and Norikazu Masuda and Tadahiko Shien and Satoru Tanaka and Yoshifumi Komoike and Nobuyuki Arima and Tetsuya Taguchi and Hideo Inaji",

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T2 - the impact of radiotherapy on second IBTR

AU - Ishitobi, Makoto

AU - Okumura, Yasuhiro

AU - Nishimura, Reiki

AU - Nakatsukasa, Katsuhiko

AU - Tanabe, Masahiko

AU - Yoshida, Atsushi

AU - Masuda, Norikazu

AU - Shien, Tadahiko

AU - Tanaka, Satoru

AU - Komoike, Yoshifumi

AU - Arima, Nobuyuki

AU - Taguchi, Tetsuya

AU - Inaji, Hideo

PY - 2014

Y1 - 2014

N2 - Objectives: There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR). Especially, the impact of radiotherapy (RT) on a second IBTR is unknown.Methods: We retrospectively analyzed 143 patients from 8 institutions in Japan who underwent repeat lumpectomy after IBTR. The risk factors of a second IBTR were assessed.Results: The median follow-up period was 4.8 years. The 5-year second IBTR-free survival rate was 80.7 %. There was a significant difference in the second IBTR-free survival rate according to RT (p = 0.0003, log-rank test). The 5-year second IBTR-free survival rates for patients who received RT after initial surgery, RT after salvage surgery, and no RT were 78.0, 93.5, and 52.7 %, respectively. Multivariate analysis revealed that RT was a significantly independent predictive factor of second IBTR-free survival.Conclusion: Repeat lumpectomy plus RT is a reasonable option in patients who did not undergo RT at the initial surgery. In contrast, caution is needed when RT is omitted in patients who have undergone repeat lumpectomy.

AB - Objectives: There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR). Especially, the impact of radiotherapy (RT) on a second IBTR is unknown.Methods: We retrospectively analyzed 143 patients from 8 institutions in Japan who underwent repeat lumpectomy after IBTR. The risk factors of a second IBTR were assessed.Results: The median follow-up period was 4.8 years. The 5-year second IBTR-free survival rate was 80.7 %. There was a significant difference in the second IBTR-free survival rate according to RT (p = 0.0003, log-rank test). The 5-year second IBTR-free survival rates for patients who received RT after initial surgery, RT after salvage surgery, and no RT were 78.0, 93.5, and 52.7 %, respectively. Multivariate analysis revealed that RT was a significantly independent predictive factor of second IBTR-free survival.Conclusion: Repeat lumpectomy plus RT is a reasonable option in patients who did not undergo RT at the initial surgery. In contrast, caution is needed when RT is omitted in patients who have undergone repeat lumpectomy.

KW - Breast cancer

KW - Breast-conserving surgery

KW - Ipsilateral breast tumor recurrence

KW - Repeat lumpectomy

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