TY - JOUR
T1 - Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery
T2 - the impact of radiotherapy on second IBTR
AU - Ishitobi, Makoto
AU - Okumura, Yasuhiro
AU - Nishimura, Reiki
AU - Nakatsukasa, Katsuhiko
AU - Tanabe, Masahiko
AU - Yoshida, Atsushi
AU - Masuda, Norikazu
AU - Shien, Tadahiko
AU - Tanaka, Satoru
AU - Komoike, Yoshifumi
AU - Arima, Nobuyuki
AU - Taguchi, Tetsuya
AU - Inaji, Hideo
N1 - Funding Information:
We thank Dr. Takuji Iwase and Dr. Takehiro Tanaka for critical reading of the manuscript. This study was supported in part by Grants-in-Aid for Scientific Research from the Japanese Breast Cancer Society. Dr. Tetsuya Taguchi received a research grant from Takeda and Chugai. Other authors declare that they have no conflict of interest.
Publisher Copyright:
© 2013, The Japanese Breast Cancer Society.
PY - 2014/11
Y1 - 2014/11
N2 - Objectives: There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR). Especially, the impact of radiotherapy (RT) on a second IBTR is unknown.Methods: We retrospectively analyzed 143 patients from 8 institutions in Japan who underwent repeat lumpectomy after IBTR. The risk factors of a second IBTR were assessed.Results: The median follow-up period was 4.8 years. The 5-year second IBTR-free survival rate was 80.7 %. There was a significant difference in the second IBTR-free survival rate according to RT (p = 0.0003, log-rank test). The 5-year second IBTR-free survival rates for patients who received RT after initial surgery, RT after salvage surgery, and no RT were 78.0, 93.5, and 52.7 %, respectively. Multivariate analysis revealed that RT was a significantly independent predictive factor of second IBTR-free survival.Conclusion: Repeat lumpectomy plus RT is a reasonable option in patients who did not undergo RT at the initial surgery. In contrast, caution is needed when RT is omitted in patients who have undergone repeat lumpectomy.
AB - Objectives: There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR). Especially, the impact of radiotherapy (RT) on a second IBTR is unknown.Methods: We retrospectively analyzed 143 patients from 8 institutions in Japan who underwent repeat lumpectomy after IBTR. The risk factors of a second IBTR were assessed.Results: The median follow-up period was 4.8 years. The 5-year second IBTR-free survival rate was 80.7 %. There was a significant difference in the second IBTR-free survival rate according to RT (p = 0.0003, log-rank test). The 5-year second IBTR-free survival rates for patients who received RT after initial surgery, RT after salvage surgery, and no RT were 78.0, 93.5, and 52.7 %, respectively. Multivariate analysis revealed that RT was a significantly independent predictive factor of second IBTR-free survival.Conclusion: Repeat lumpectomy plus RT is a reasonable option in patients who did not undergo RT at the initial surgery. In contrast, caution is needed when RT is omitted in patients who have undergone repeat lumpectomy.
KW - Breast cancer
KW - Breast-conserving surgery
KW - Ipsilateral breast tumor recurrence
KW - Repeat lumpectomy
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U2 - 10.1007/s12282-013-0454-6
DO - 10.1007/s12282-013-0454-6
M3 - Article
C2 - 23483442
AN - SCOPUS:84874697339
VL - 21
SP - 754
EP - 760
JO - Breast Cancer
JF - Breast Cancer
SN - 1340-6868
IS - 6
ER -
