Repair roles of hSMUG1 assessed by damage specificity and cellular activity.

Aya Masaoka, Mayumi Matsubara, Tamon Tanaka, Hiroaki Terato, Yoshihiko Ohyama, Kihei Kubo, Hiroshi Ide

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1) was previously identified as a putative backup enzyme of major mammalian uracil-DNA glycosylase (UDG). However, the subsequent studies have shown conflicting results about the substrate specificity of SMUG1. In the present study, to clarify the repair role of SMUG1, we determined the damage specificity of purified human SMUG1 (hSMUG1) and its contribution to repair of oxidized bases in HeLa cell extracts.

Original languageEnglish
Pages (from-to)263-264
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number3
DOIs
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Medicine(all)

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