Repair mechanism of DNA-protein cross-link damage in Escherichia coli.

Toshiaki Nakano, Soh Morishita, Hiroaki Terato, Seung Pil Pack, Keisuke Makino, Hiroshi Ide

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

DNA-protein cross-link (DPC) damage is produced by varieties of genotoxic agents such as ionizing radiation, UV light, aldehydes, and some chemotherapeutic compounds. DPCs would be harmful to cells since proteins immobilized on DNA strands could hamper DNA transactions in cells. However, it has not been clarified how DPCs are repaired in cells. In the present study, we prepared DNA substrates containing defined DPCs and tested them for repair enzymes. We also examined the sensitivity of Escherichia coli to DPC-inducing agents.

Original languageEnglish
Pages (from-to)213-214
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number51
Publication statusPublished - Dec 1 2007
Externally publishedYes

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DNA Repair
Escherichia coli
DNA
Immobilized Nucleic Acids
Ultraviolet Rays
Ionizing Radiation
Aldehydes
link protein
Enzymes
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nakano, T., Morishita, S., Terato, H., Pack, S. P., Makino, K., & Ide, H. (2007). Repair mechanism of DNA-protein cross-link damage in Escherichia coli. Nucleic acids symposium series (2004), (51), 213-214.

Repair mechanism of DNA-protein cross-link damage in Escherichia coli. / Nakano, Toshiaki; Morishita, Soh; Terato, Hiroaki; Pack, Seung Pil; Makino, Keisuke; Ide, Hiroshi.

In: Nucleic acids symposium series (2004), No. 51, 01.12.2007, p. 213-214.

Research output: Contribution to journalArticle

Nakano, T, Morishita, S, Terato, H, Pack, SP, Makino, K & Ide, H 2007, 'Repair mechanism of DNA-protein cross-link damage in Escherichia coli.', Nucleic acids symposium series (2004), no. 51, pp. 213-214.
Nakano, Toshiaki ; Morishita, Soh ; Terato, Hiroaki ; Pack, Seung Pil ; Makino, Keisuke ; Ide, Hiroshi. / Repair mechanism of DNA-protein cross-link damage in Escherichia coli. In: Nucleic acids symposium series (2004). 2007 ; No. 51. pp. 213-214.
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