Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep

Naoya Iguchi, Junko Kosaka, Lindsea C. Booth, Yoko Iguchi, Roger G. Evans, Rinaldo Bellomo, Clive N. May, Yugeesh R. Lankadeva

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Global and intra-renal perfusion and oxygenation may be affected by the choice of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on renal blood flow (RBF) and intra-renal perfusion and oxygenation, and assessed how these were associated with renal sympathetic nerve activity (RSNA). Methods: A renal artery flow probe and laser Doppler and oxygen-sensing probes were surgically implanted in the renal medulla and cortex in 20 Merino ewes. RSNA was measured in 12 additional ewes. We compared the effects of volatile or i.v. anaesthesia on global RBF, renal oxygen delivery (RDO 2 ), intra-renal perfusion, and RSNA with the non-anaesthetised state on postoperative day 3 as control reference. Results: Compared with a non-anaesthetised state, volatile anaesthesia reduced global RBF [–76 (82–68)%], RDO 2 [−76 (83–71)%], and cortical [–68 (74–54)%] and medullary [–76 (84–72)%] perfusion. I.V. anaesthesia reduced RBF [–55 (67–38)%], RDO 2 [–55 (65–44)%], and cortical [–27 (45–6)%] and medullary [–35 (48–30)%] perfusion, but to a lesser extent than volatile anaesthesia. Renal PO 2 was not influenced by anaesthesia, whilst RSNA was elevated during volatile, but not during i.v. anaesthesia. Conclusions: Volatile and i.v. general anaesthesia markedly reduced global RBF, RDO 2 , and regional kidney perfusion. These effects were greater with volatile anaesthesia, and were paralleled by an increase in RSNA. Our findings suggest a neurogenic modulatory effect of anaesthetics on renal perfusion and oxygenation.

Original languageEnglish
Pages (from-to)342-349
Number of pages8
JournalBritish Journal of Anaesthesia
Volume122
Issue number3
DOIs
Publication statusPublished - Mar 1 2019
Externally publishedYes

Fingerprint

Intravenous Anesthesia
General Anesthesia
Sheep
Perfusion
Kidney
Renal Circulation
Anesthesia
Anesthetics
Oxygen
Isoflurane
Fentanyl
Propofol
Renal Artery

Keywords

  • fentanyl
  • i.v. anaesthesia
  • isoflurane
  • propofol
  • renal blood flow
  • renal perfusion
  • renal sympathetic nerve activity
  • volatile anaesthesia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep. / Iguchi, Naoya; Kosaka, Junko; Booth, Lindsea C.; Iguchi, Yoko; Evans, Roger G.; Bellomo, Rinaldo; May, Clive N.; Lankadeva, Yugeesh R.

In: British Journal of Anaesthesia, Vol. 122, No. 3, 01.03.2019, p. 342-349.

Research output: Contribution to journalArticle

Iguchi, Naoya ; Kosaka, Junko ; Booth, Lindsea C. ; Iguchi, Yoko ; Evans, Roger G. ; Bellomo, Rinaldo ; May, Clive N. ; Lankadeva, Yugeesh R. / Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep. In: British Journal of Anaesthesia. 2019 ; Vol. 122, No. 3. pp. 342-349.
@article{824955a3100a438f944d9412bd04fb1e,
title = "Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep",
abstract = "Background: Global and intra-renal perfusion and oxygenation may be affected by the choice of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on renal blood flow (RBF) and intra-renal perfusion and oxygenation, and assessed how these were associated with renal sympathetic nerve activity (RSNA). Methods: A renal artery flow probe and laser Doppler and oxygen-sensing probes were surgically implanted in the renal medulla and cortex in 20 Merino ewes. RSNA was measured in 12 additional ewes. We compared the effects of volatile or i.v. anaesthesia on global RBF, renal oxygen delivery (RDO 2 ), intra-renal perfusion, and RSNA with the non-anaesthetised state on postoperative day 3 as control reference. Results: Compared with a non-anaesthetised state, volatile anaesthesia reduced global RBF [–76 (82–68){\%}], RDO 2 [−76 (83–71){\%}], and cortical [–68 (74–54){\%}] and medullary [–76 (84–72){\%}] perfusion. I.V. anaesthesia reduced RBF [–55 (67–38){\%}], RDO 2 [–55 (65–44){\%}], and cortical [–27 (45–6){\%}] and medullary [–35 (48–30){\%}] perfusion, but to a lesser extent than volatile anaesthesia. Renal PO 2 was not influenced by anaesthesia, whilst RSNA was elevated during volatile, but not during i.v. anaesthesia. Conclusions: Volatile and i.v. general anaesthesia markedly reduced global RBF, RDO 2 , and regional kidney perfusion. These effects were greater with volatile anaesthesia, and were paralleled by an increase in RSNA. Our findings suggest a neurogenic modulatory effect of anaesthetics on renal perfusion and oxygenation.",
keywords = "fentanyl, i.v. anaesthesia, isoflurane, propofol, renal blood flow, renal perfusion, renal sympathetic nerve activity, volatile anaesthesia",
author = "Naoya Iguchi and Junko Kosaka and Booth, {Lindsea C.} and Yoko Iguchi and Evans, {Roger G.} and Rinaldo Bellomo and May, {Clive N.} and Lankadeva, {Yugeesh R.}",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.bja.2018.11.018",
language = "English",
volume = "122",
pages = "342--349",
journal = "British Journal of Anaesthesia",
issn = "0007-0912",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep

AU - Iguchi, Naoya

AU - Kosaka, Junko

AU - Booth, Lindsea C.

AU - Iguchi, Yoko

AU - Evans, Roger G.

AU - Bellomo, Rinaldo

AU - May, Clive N.

AU - Lankadeva, Yugeesh R.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Global and intra-renal perfusion and oxygenation may be affected by the choice of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on renal blood flow (RBF) and intra-renal perfusion and oxygenation, and assessed how these were associated with renal sympathetic nerve activity (RSNA). Methods: A renal artery flow probe and laser Doppler and oxygen-sensing probes were surgically implanted in the renal medulla and cortex in 20 Merino ewes. RSNA was measured in 12 additional ewes. We compared the effects of volatile or i.v. anaesthesia on global RBF, renal oxygen delivery (RDO 2 ), intra-renal perfusion, and RSNA with the non-anaesthetised state on postoperative day 3 as control reference. Results: Compared with a non-anaesthetised state, volatile anaesthesia reduced global RBF [–76 (82–68)%], RDO 2 [−76 (83–71)%], and cortical [–68 (74–54)%] and medullary [–76 (84–72)%] perfusion. I.V. anaesthesia reduced RBF [–55 (67–38)%], RDO 2 [–55 (65–44)%], and cortical [–27 (45–6)%] and medullary [–35 (48–30)%] perfusion, but to a lesser extent than volatile anaesthesia. Renal PO 2 was not influenced by anaesthesia, whilst RSNA was elevated during volatile, but not during i.v. anaesthesia. Conclusions: Volatile and i.v. general anaesthesia markedly reduced global RBF, RDO 2 , and regional kidney perfusion. These effects were greater with volatile anaesthesia, and were paralleled by an increase in RSNA. Our findings suggest a neurogenic modulatory effect of anaesthetics on renal perfusion and oxygenation.

AB - Background: Global and intra-renal perfusion and oxygenation may be affected by the choice of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on renal blood flow (RBF) and intra-renal perfusion and oxygenation, and assessed how these were associated with renal sympathetic nerve activity (RSNA). Methods: A renal artery flow probe and laser Doppler and oxygen-sensing probes were surgically implanted in the renal medulla and cortex in 20 Merino ewes. RSNA was measured in 12 additional ewes. We compared the effects of volatile or i.v. anaesthesia on global RBF, renal oxygen delivery (RDO 2 ), intra-renal perfusion, and RSNA with the non-anaesthetised state on postoperative day 3 as control reference. Results: Compared with a non-anaesthetised state, volatile anaesthesia reduced global RBF [–76 (82–68)%], RDO 2 [−76 (83–71)%], and cortical [–68 (74–54)%] and medullary [–76 (84–72)%] perfusion. I.V. anaesthesia reduced RBF [–55 (67–38)%], RDO 2 [–55 (65–44)%], and cortical [–27 (45–6)%] and medullary [–35 (48–30)%] perfusion, but to a lesser extent than volatile anaesthesia. Renal PO 2 was not influenced by anaesthesia, whilst RSNA was elevated during volatile, but not during i.v. anaesthesia. Conclusions: Volatile and i.v. general anaesthesia markedly reduced global RBF, RDO 2 , and regional kidney perfusion. These effects were greater with volatile anaesthesia, and were paralleled by an increase in RSNA. Our findings suggest a neurogenic modulatory effect of anaesthetics on renal perfusion and oxygenation.

KW - fentanyl

KW - i.v. anaesthesia

KW - isoflurane

KW - propofol

KW - renal blood flow

KW - renal perfusion

KW - renal sympathetic nerve activity

KW - volatile anaesthesia

UR - http://www.scopus.com/inward/record.url?scp=85059682610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059682610&partnerID=8YFLogxK

U2 - 10.1016/j.bja.2018.11.018

DO - 10.1016/j.bja.2018.11.018

M3 - Article

VL - 122

SP - 342

EP - 349

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

IS - 3

ER -