Renal pathology of ANCA-related vasculitis: Proposal for standardization of pathological diagnosis in Japan

Kensuke Joh, Eri Muso, Hidekazu Shigematsu, Masato Nose, Michio Nagata, Yoshihiro Arimura, Wako Yumura, Takashi Wada, Kousaku Nitta, Hirofumi Makino, Yoshio Taguma, Hidetoshi Kaneoka, Yuhsuke Suzuki, Masaki Kobayashi, Akio Koyama, Joichi Usui, Hiroshi Hashimoto, Shoichi Ozaki, Yasuhiko Tomino, Kunihiro Yamagata

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: In Japan, systematic evaluation of the histologic parameters of anti-neutrophil cytoplasmic autoantibodies (ANCA)-related vasculitis has been performed according to the Japanese classification by Shigematsu et al. However, this classification is quite different from that of the European Vasculitis Study Group (EUVAS) classification. Therefore, a histological common basis is needed to compare Japanese histological data with the international database. Method: Histological parameters concerning glomerular, tubulointerstitial, and vascular lesions of ANCA-related vasculitis, which are indispensable for clinical management, were elucidated and defined by reviewing, utilizing the merits of, and amending the two scoring systems. Results and conclusion: A new comprehensive and standardized scoring system, by which histological quantitative assessment can provide evidence for therapy planning, has been developed for renal biopsy of Japanese ANCA-related vasculitis.

Original languageEnglish
Pages (from-to)277-291
Number of pages15
JournalClinical and Experimental Nephrology
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 2008

Keywords

  • ANCA-related vasculitis
  • Glomerulonephritis
  • Histopathological evaluation
  • Microscopic polyangiitis
  • Renal biopsy
  • Renal limited vasculitis
  • Wegener's granulomatosis

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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    Joh, K., Muso, E., Shigematsu, H., Nose, M., Nagata, M., Arimura, Y., Yumura, W., Wada, T., Nitta, K., Makino, H., Taguma, Y., Kaneoka, H., Suzuki, Y., Kobayashi, M., Koyama, A., Usui, J., Hashimoto, H., Ozaki, S., Tomino, Y., & Yamagata, K. (2008). Renal pathology of ANCA-related vasculitis: Proposal for standardization of pathological diagnosis in Japan. Clinical and Experimental Nephrology, 12(4), 277-291. https://doi.org/10.1007/s10157-008-0052-7