Renal handling of adipokines

Hitomi Kataoka, Kumar Sharma

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is now considered as one of the strongest risk factors for all cause mortality and cardiovascular events. However, the link between CKD and systemic events is unclear. The role of the kidney is primarily considered a target organ during the development of obesity as altered production of adipokines from visceral adipocytes, however, it should also be recognized that the kidney itself could alter the clearance and production of adiopokines. In this chapter, we provide a discussion of renal handling of a variety of adipokines. Specifically, there is a growing body of data supporting a major role for the kidney in clearance of insulin, leptin, and TGF-β. In addition, plasminogen activator inhibitor-1, vascular endothelial growth factor, angiotensin II, and resistin may also be altered by the kidney. The mechanistic regulation of renal handling by the kidney of a variety of circulating adipokines, however is poorly defined. We conclude that the kidney has pivotal roles in the regulation of adipokines and that altered renal handling of adipokines may contribute to the imbalance of factors that ultimately lead to progressive cardiovascular and systemic disease.

Original languageEnglish
Title of host publicationObesity and the Kidney
Pages91-105
Number of pages15
Volume151
DOIs
Publication statusPublished - 2006
Externally publishedYes

Publication series

NameContributions to Nephrology
Volume151
ISSN (Print)03025144

Fingerprint

Adipokines
Kidney
Chronic Renal Insufficiency
Resistin
Plasminogen Activator Inhibitor 1
Leptin
Adipocytes
Angiotensin II
Vascular Endothelial Growth Factor A
Cardiovascular Diseases
Obesity
Insulin
Mortality

ASJC Scopus subject areas

  • Medicine(all)
  • Nephrology

Cite this

Kataoka, H., & Sharma, K. (2006). Renal handling of adipokines. In Obesity and the Kidney (Vol. 151, pp. 91-105). (Contributions to Nephrology; Vol. 151). https://doi.org/10.1159/000095321

Renal handling of adipokines. / Kataoka, Hitomi; Sharma, Kumar.

Obesity and the Kidney. Vol. 151 2006. p. 91-105 (Contributions to Nephrology; Vol. 151).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kataoka, H & Sharma, K 2006, Renal handling of adipokines. in Obesity and the Kidney. vol. 151, Contributions to Nephrology, vol. 151, pp. 91-105. https://doi.org/10.1159/000095321
Kataoka H, Sharma K. Renal handling of adipokines. In Obesity and the Kidney. Vol. 151. 2006. p. 91-105. (Contributions to Nephrology). https://doi.org/10.1159/000095321
Kataoka, Hitomi ; Sharma, Kumar. / Renal handling of adipokines. Obesity and the Kidney. Vol. 151 2006. pp. 91-105 (Contributions to Nephrology).
@inbook{de9f48caf75f4b26843e46d4a9c1fc22,
title = "Renal handling of adipokines",
abstract = "Chronic kidney disease (CKD) is now considered as one of the strongest risk factors for all cause mortality and cardiovascular events. However, the link between CKD and systemic events is unclear. The role of the kidney is primarily considered a target organ during the development of obesity as altered production of adipokines from visceral adipocytes, however, it should also be recognized that the kidney itself could alter the clearance and production of adiopokines. In this chapter, we provide a discussion of renal handling of a variety of adipokines. Specifically, there is a growing body of data supporting a major role for the kidney in clearance of insulin, leptin, and TGF-β. In addition, plasminogen activator inhibitor-1, vascular endothelial growth factor, angiotensin II, and resistin may also be altered by the kidney. The mechanistic regulation of renal handling by the kidney of a variety of circulating adipokines, however is poorly defined. We conclude that the kidney has pivotal roles in the regulation of adipokines and that altered renal handling of adipokines may contribute to the imbalance of factors that ultimately lead to progressive cardiovascular and systemic disease.",
author = "Hitomi Kataoka and Kumar Sharma",
year = "2006",
doi = "10.1159/000095321",
language = "English",
isbn = "3805581645",
volume = "151",
series = "Contributions to Nephrology",
pages = "91--105",
booktitle = "Obesity and the Kidney",

}

TY - CHAP

T1 - Renal handling of adipokines

AU - Kataoka, Hitomi

AU - Sharma, Kumar

PY - 2006

Y1 - 2006

N2 - Chronic kidney disease (CKD) is now considered as one of the strongest risk factors for all cause mortality and cardiovascular events. However, the link between CKD and systemic events is unclear. The role of the kidney is primarily considered a target organ during the development of obesity as altered production of adipokines from visceral adipocytes, however, it should also be recognized that the kidney itself could alter the clearance and production of adiopokines. In this chapter, we provide a discussion of renal handling of a variety of adipokines. Specifically, there is a growing body of data supporting a major role for the kidney in clearance of insulin, leptin, and TGF-β. In addition, plasminogen activator inhibitor-1, vascular endothelial growth factor, angiotensin II, and resistin may also be altered by the kidney. The mechanistic regulation of renal handling by the kidney of a variety of circulating adipokines, however is poorly defined. We conclude that the kidney has pivotal roles in the regulation of adipokines and that altered renal handling of adipokines may contribute to the imbalance of factors that ultimately lead to progressive cardiovascular and systemic disease.

AB - Chronic kidney disease (CKD) is now considered as one of the strongest risk factors for all cause mortality and cardiovascular events. However, the link between CKD and systemic events is unclear. The role of the kidney is primarily considered a target organ during the development of obesity as altered production of adipokines from visceral adipocytes, however, it should also be recognized that the kidney itself could alter the clearance and production of adiopokines. In this chapter, we provide a discussion of renal handling of a variety of adipokines. Specifically, there is a growing body of data supporting a major role for the kidney in clearance of insulin, leptin, and TGF-β. In addition, plasminogen activator inhibitor-1, vascular endothelial growth factor, angiotensin II, and resistin may also be altered by the kidney. The mechanistic regulation of renal handling by the kidney of a variety of circulating adipokines, however is poorly defined. We conclude that the kidney has pivotal roles in the regulation of adipokines and that altered renal handling of adipokines may contribute to the imbalance of factors that ultimately lead to progressive cardiovascular and systemic disease.

UR - http://www.scopus.com/inward/record.url?scp=33748073463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748073463&partnerID=8YFLogxK

U2 - 10.1159/000095321

DO - 10.1159/000095321

M3 - Chapter

C2 - 16929135

AN - SCOPUS:33748073463

SN - 3805581645

SN - 9783805581646

VL - 151

T3 - Contributions to Nephrology

SP - 91

EP - 105

BT - Obesity and the Kidney

ER -