Renal distribution of Vasohibin-1 in patients with chronic kidney disease

Norikazu Hinamoto, Yohei Maeshima, Daisuke Saito, Hiroko Yamasakr, Katsuyuki Tanabe, Tatsuyo Nasu, Hiroyuki Watatani, Haruyo Ujike, Masaru Kinomura, Hitoshi Sugiyama, Hikaru Sonoda, Naoki Kanomata, Yasufumi Sate, Hirofumi Makino

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, /> = 0.001) or cortex (r = 0.64, p< 0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r = 0.34, p = 0.02), 3) the glomerular VEGFR-2+ area and the number of VASH 1+ cells in the glomerulus (r = 0.44, p = 0.01) or medulla (r = 0.63, p = 0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.

Original languageEnglish
Pages (from-to)219-233
Number of pages15
JournalActa medica Okayama
Volume68
Issue number4
Publication statusPublished - 2014

Keywords

  • Chronic kidney disease
  • Inflammation
  • VEGF-A
  • VEGFR-2
  • Vasohibin-1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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