Remission of Congenital Multi-system Type Langerhans Cell Histiocytosis with Chemotherapy

Kosuke Tamefusa, Hisashi Ishida, Kana Washio, Toshiaki Ishida, Hirosuke Morita, Akira Shimada

Research output: Contribution to journalArticle

Abstract

Patients with multi-system (MS)-type langerhans cell histiocytosis (LCH) show poor outcomes, especially congenital MS LCH cases were shown in high mortality rate. We experienced a congenital case of MS LCH with high risk organs, who needed intensive respiratory support after birth. Even though intensive chemotherapy was discontinued, this patient's lung LCH lesions gradually became reduced and his respiratory condition recovered; therefore, we restarted and completed maintenance chemotherapy. The patient maintained complete remission for more than 4 years after the end of chemotherapy. Our case suggests that congenital MS LCH even with severe organ involvement can be treated successfully with chemotherapy.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalActa medica Okayama
Volume73
Issue number1
DOIs
Publication statusPublished - Feb 1 2019

Fingerprint

Langerhans Cell Histiocytosis
Chemotherapy
Drug Therapy
Maintenance Chemotherapy
Parturition
Lung
Mortality

Keywords

  • congenital
  • Langerhans-cell histiocytosis
  • multisystem type

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Remission of Congenital Multi-system Type Langerhans Cell Histiocytosis with Chemotherapy. / Tamefusa, Kosuke; Ishida, Hisashi; Washio, Kana; Ishida, Toshiaki; Morita, Hirosuke; Shimada, Akira.

In: Acta medica Okayama, Vol. 73, No. 1, 01.02.2019, p. 61-65.

Research output: Contribution to journalArticle

Tamefusa, Kosuke ; Ishida, Hisashi ; Washio, Kana ; Ishida, Toshiaki ; Morita, Hirosuke ; Shimada, Akira. / Remission of Congenital Multi-system Type Langerhans Cell Histiocytosis with Chemotherapy. In: Acta medica Okayama. 2019 ; Vol. 73, No. 1. pp. 61-65.
@article{bbee052ea6fd4131af84b9615279405a,
title = "Remission of Congenital Multi-system Type Langerhans Cell Histiocytosis with Chemotherapy",
abstract = "Patients with multi-system (MS)-type langerhans cell histiocytosis (LCH) show poor outcomes, especially congenital MS LCH cases were shown in high mortality rate. We experienced a congenital case of MS LCH with high risk organs, who needed intensive respiratory support after birth. Even though intensive chemotherapy was discontinued, this patient's lung LCH lesions gradually became reduced and his respiratory condition recovered; therefore, we restarted and completed maintenance chemotherapy. The patient maintained complete remission for more than 4 years after the end of chemotherapy. Our case suggests that congenital MS LCH even with severe organ involvement can be treated successfully with chemotherapy.",
keywords = "congenital, Langerhans-cell histiocytosis, multisystem type",
author = "Kosuke Tamefusa and Hisashi Ishida and Kana Washio and Toshiaki Ishida and Hirosuke Morita and Akira Shimada",
year = "2019",
month = "2",
day = "1",
doi = "10.18926/AMO/56459",
language = "English",
volume = "73",
pages = "61--65",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "1",

}

TY - JOUR

T1 - Remission of Congenital Multi-system Type Langerhans Cell Histiocytosis with Chemotherapy

AU - Tamefusa, Kosuke

AU - Ishida, Hisashi

AU - Washio, Kana

AU - Ishida, Toshiaki

AU - Morita, Hirosuke

AU - Shimada, Akira

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Patients with multi-system (MS)-type langerhans cell histiocytosis (LCH) show poor outcomes, especially congenital MS LCH cases were shown in high mortality rate. We experienced a congenital case of MS LCH with high risk organs, who needed intensive respiratory support after birth. Even though intensive chemotherapy was discontinued, this patient's lung LCH lesions gradually became reduced and his respiratory condition recovered; therefore, we restarted and completed maintenance chemotherapy. The patient maintained complete remission for more than 4 years after the end of chemotherapy. Our case suggests that congenital MS LCH even with severe organ involvement can be treated successfully with chemotherapy.

AB - Patients with multi-system (MS)-type langerhans cell histiocytosis (LCH) show poor outcomes, especially congenital MS LCH cases were shown in high mortality rate. We experienced a congenital case of MS LCH with high risk organs, who needed intensive respiratory support after birth. Even though intensive chemotherapy was discontinued, this patient's lung LCH lesions gradually became reduced and his respiratory condition recovered; therefore, we restarted and completed maintenance chemotherapy. The patient maintained complete remission for more than 4 years after the end of chemotherapy. Our case suggests that congenital MS LCH even with severe organ involvement can be treated successfully with chemotherapy.

KW - congenital

KW - Langerhans-cell histiocytosis

KW - multisystem type

UR - http://www.scopus.com/inward/record.url?scp=85062401527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062401527&partnerID=8YFLogxK

U2 - 10.18926/AMO/56459

DO - 10.18926/AMO/56459

M3 - Article

VL - 73

SP - 61

EP - 65

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 1

ER -