Remarkable enhancement of the rate of the intramolecular morita-baylis-hillman reaction by the combination of a nucleophilic catalyst and 1,3-diphenyl-2-thiourea

Hiroki Mandai, Keita Shimowaki, Koichi Mitsudo, Seiji Suga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The rate of the intramolecular Morita-Baylis-Hillman (MBH) reaction is remarkably enhanced by the combination of catalytic amounts of a nucleophilic catalyst (4-dimethylaminopyridine (DMAP), 4-pyrrolidinopyridine (PPY), or PBu3) and 1,3-diphenyl-2-thiourea, and the desired MBH adducts are obtained in good to high yields within a few hours.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalAsian Journal of Organic Chemistry
Volume3
Issue number4
DOIs
Publication statusPublished - Apr 2014

Keywords

  • 4-dimethylaminopyridine
  • Ketones
  • Morita-Baylis-Hillman reaction
  • Nucleophilic catalysts
  • Thioureas

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Remarkable enhancement of the rate of the intramolecular morita-baylis-hillman reaction by the combination of a nucleophilic catalyst and 1,3-diphenyl-2-thiourea'. Together they form a unique fingerprint.

  • Cite this