Remarkable enhancement of the rate of the intramolecular morita-baylis-hillman reaction by the combination of a nucleophilic catalyst and 1,3-diphenyl-2-thiourea

Hiroki Mandai, Keita Shimowaki, Koichi Mitsudo, Seiji Suga

Research output: Contribution to journalArticle

6 Citations (Scopus)


The rate of the intramolecular Morita-Baylis-Hillman (MBH) reaction is remarkably enhanced by the combination of catalytic amounts of a nucleophilic catalyst (4-dimethylaminopyridine (DMAP), 4-pyrrolidinopyridine (PPY), or PBu3) and 1,3-diphenyl-2-thiourea, and the desired MBH adducts are obtained in good to high yields within a few hours.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalAsian Journal of Organic Chemistry
Issue number4
Publication statusPublished - 2014



  • 4-dimethylaminopyridine
  • Ketones
  • Morita-Baylis-Hillman reaction
  • Nucleophilic catalysts
  • Thioureas

ASJC Scopus subject areas

  • Organic Chemistry

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