Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese

Hirofumi Tomiyama, Takahide Kohro, Yukihito Higashi, Bonpei Takase, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke OhyaTaiji Furukawa, Hiroshi Itoh, Hisao Ikeda, Akira Yamashina

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Aims: For the standardization of flow-mediated vasodilatation (FMD) assessment as a clinical tool, validation of its reliability across multiple institutions and the establishment of normal/reference values based on reliable data from multiple institutions are needed. Methods and results: In Study 1, assessment of FMD (scan recording and analysis) using an ultrasonographic semi-automatic measuring system (sFMD) was conducted at 18 participating institutions (sFMD-INST) (n = 981). All of the brachial arterial scans were also analyzed at a core laboratory (sFMD-COLB). After 111 subjects with inadequate sFMD recordings were excluded (n = 880), the correlation between the sFMD-INST and sFMD-COLB improved from R = 0.725 to R = 0.838 (p <0.001). In Study 2, based on good-quality sFMD data obtained from 6660 subjects without cardiovascular disease (CVD) and 729 subjects with CVD from 27 institutions, reference values of sFMD are proposed by the Framingham risk score (FRS)-based risk categories and according to gender and age. The receiver-operating characteristic curve analysis revealed a significant power of sFMD values in reference ranges to discriminate between subjects with and without CVD (e.g., area under curve = 0.64 in the FRS-low risk group). Conclusions: When the analysis was limited to cases with clear sFMD recordings, the reliability of the sFMD assessment (scan and its analysis) conducted in individual institutions appeared to be acceptable. Reference sFMD values (lower cuff occlusion) for the Japanese population are proposed based on reliable data derived from multiple institutions, and the reference values may identify patients without advanced vascular damage.

Original languageEnglish
Pages (from-to)433-442
Number of pages10
JournalAtherosclerosis
Volume242
Issue number2
DOIs
Publication statusPublished - Oct 1 2015

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Reference Values
Cardiovascular Diseases
Vasodilation
ROC Curve
Area Under Curve
Blood Vessels
Arm
Population

Keywords

  • Endothelial function
  • Reference value
  • Reliability
  • Standardization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese. / Tomiyama, Hirofumi; Kohro, Takahide; Higashi, Yukihito; Takase, Bonpei; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Itoh, Hiroshi; Ikeda, Hisao; Yamashina, Akira.

In: Atherosclerosis, Vol. 242, No. 2, 01.10.2015, p. 433-442.

Research output: Contribution to journalArticle

Tomiyama, H, Kohro, T, Higashi, Y, Takase, B, Suzuki, T, Ishizu, T, Ueda, S, Yamazaki, T, Furumoto, T, Kario, K, Inoue, T, Koba, S, Watanabe, K, Takemoto, Y, Hano, T, Sata, M, Ishibashi, Y, Node, K, Maemura, K, Ohya, Y, Furukawa, T, Itoh, H, Ikeda, H & Yamashina, A 2015, 'Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese', Atherosclerosis, vol. 242, no. 2, pp. 433-442. https://doi.org/10.1016/j.atherosclerosis.2015.08.001
Tomiyama, Hirofumi ; Kohro, Takahide ; Higashi, Yukihito ; Takase, Bonpei ; Suzuki, Toru ; Ishizu, Tomoko ; Ueda, Shinichiro ; Yamazaki, Tsutomu ; Furumoto, Tomoo ; Kario, Kazuomi ; Inoue, Teruo ; Koba, Shinji ; Watanabe, Kentaro ; Takemoto, Yasuhiko ; Hano, Takuzo ; Sata, Masataka ; Ishibashi, Yutaka ; Node, Koichi ; Maemura, Koji ; Ohya, Yusuke ; Furukawa, Taiji ; Itoh, Hiroshi ; Ikeda, Hisao ; Yamashina, Akira. / Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese. In: Atherosclerosis. 2015 ; Vol. 242, No. 2. pp. 433-442.
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AU - Tomiyama, Hirofumi

AU - Kohro, Takahide

AU - Higashi, Yukihito

AU - Takase, Bonpei

AU - Suzuki, Toru

AU - Ishizu, Tomoko

AU - Ueda, Shinichiro

AU - Yamazaki, Tsutomu

AU - Furumoto, Tomoo

AU - Kario, Kazuomi

AU - Inoue, Teruo

AU - Koba, Shinji

AU - Watanabe, Kentaro

AU - Takemoto, Yasuhiko

AU - Hano, Takuzo

AU - Sata, Masataka

AU - Ishibashi, Yutaka

AU - Node, Koichi

AU - Maemura, Koji

AU - Ohya, Yusuke

AU - Furukawa, Taiji

AU - Itoh, Hiroshi

AU - Ikeda, Hisao

AU - Yamashina, Akira

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N2 - Aims: For the standardization of flow-mediated vasodilatation (FMD) assessment as a clinical tool, validation of its reliability across multiple institutions and the establishment of normal/reference values based on reliable data from multiple institutions are needed. Methods and results: In Study 1, assessment of FMD (scan recording and analysis) using an ultrasonographic semi-automatic measuring system (sFMD) was conducted at 18 participating institutions (sFMD-INST) (n = 981). All of the brachial arterial scans were also analyzed at a core laboratory (sFMD-COLB). After 111 subjects with inadequate sFMD recordings were excluded (n = 880), the correlation between the sFMD-INST and sFMD-COLB improved from R = 0.725 to R = 0.838 (p <0.001). In Study 2, based on good-quality sFMD data obtained from 6660 subjects without cardiovascular disease (CVD) and 729 subjects with CVD from 27 institutions, reference values of sFMD are proposed by the Framingham risk score (FRS)-based risk categories and according to gender and age. The receiver-operating characteristic curve analysis revealed a significant power of sFMD values in reference ranges to discriminate between subjects with and without CVD (e.g., area under curve = 0.64 in the FRS-low risk group). Conclusions: When the analysis was limited to cases with clear sFMD recordings, the reliability of the sFMD assessment (scan and its analysis) conducted in individual institutions appeared to be acceptable. Reference sFMD values (lower cuff occlusion) for the Japanese population are proposed based on reliable data derived from multiple institutions, and the reference values may identify patients without advanced vascular damage.

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