Relevance of CYP3A5 Expression on the Clinical Outcome of Patients with Renal Cell Carcinoma

Jun Matsumoto, Yumi Kotera, Shogo Watari, Koichi Takeuchi, Hideo Ueki, Toshihiro Koyama, Koichiro Wada, Masachika Fujiyoshi, Yasutomo Nasu, Noritaka Ariyoshi

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: This study aimed to elucidate the detailed characteristics of CYP3A5 expression and the association between CYP3A5 expression and clinical outcomes in patients with renal cell carcinoma (RCC). Patients and Methods: This study retrospectively enrolled 124 Japanese patients with RCC treated at the Okayama University Hospital. The commonest CYP3A5 gene polymorphism, CYP3A5*3, and expression levels of CYP3A5 mRNA and protein in each tissue were examined. Results: Expression of CYP3A5 mRNA and protein in RCC tissues was significantly down-regulated compared to that in adjacent normal tissues. High level of CYP3A5 mRNA expression significantly extended cancer-specific survival (p=0.004) and overall survival (p=0.002). The CYP3A5 mRNA expression level was identified as a significant independent prognostic factor for both cancer-specific survival and overall survival. Conclusion: CYP3A5 could serve as a potential marker for prognostication and treatment planning for patients with RCC.

Original languageEnglish
Pages (from-to)2511-2521
Number of pages11
JournalAnticancer research
Volume41
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • CYP3A5 protein
  • Cytochrome P450 CYP3A
  • Human
  • Renal cell carcinoma treatment outcome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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