Abstract
Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin. Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin. About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions. Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA.
| Original language | English |
|---|---|
| Article number | 7051523 |
| Journal | Journal of Nanotechnology |
| Volume | 2016 |
| DOIs | |
| Publication status | Published - 2016 |
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ASJC Scopus subject areas
- Materials Science(all)
Cite this
Release of siRNA from Liposomes Induced by Curcumin. / Fujita, Kazuyo; Hiramatsu, Yoshie; Minematsu, Hideki; Somiya, Masaharu; Kuroda, Shun'ichi; Seno, Masaharu; Hinuma, Shuji.
In: Journal of Nanotechnology, Vol. 2016, 7051523, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Release of siRNA from Liposomes Induced by Curcumin
AU - Fujita, Kazuyo
AU - Hiramatsu, Yoshie
AU - Minematsu, Hideki
AU - Somiya, Masaharu
AU - Kuroda, Shun'ichi
AU - Seno, Masaharu
AU - Hinuma, Shuji
PY - 2016
Y1 - 2016
N2 - Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin. Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin. About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions. Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA.
AB - Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin. Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin. About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions. Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA.
UR - http://www.scopus.com/inward/record.url?scp=85000417128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85000417128&partnerID=8YFLogxK
U2 - 10.1155/2016/7051523
DO - 10.1155/2016/7051523
M3 - Article
VL - 2016
JO - Journal of Nanotechnology
JF - Journal of Nanotechnology
SN - 1687-9503
M1 - 7051523
ER -