Relatively benign clinical course in asymptomatic patients with Brugada-type electrocardiogram without family history of sudden death

Shiho Takenaka, Kengo Fukushima Kusano, Kenichi Hisamatsu, Satoshi Nagase, Kazufumi Nakamura, Hiroshi Morita, Hiromi Matsubara, Tetsuro Emori, Tohru Ohe

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Introduction: The incidence of sudden death or ventricular fibrillation (VF) in asymptomatic Brugada syndrome patients with a family history of sudden death is reported to be very high. However, there are few reports on the prognosis of asymptomatic Brugada syndrome patients without a family history of sudden death. Methods and Results: Eleven patients (all male; mean age 40.5 ± 9.6 years, range 26 to 56) with asymptomatic Brugada-type ECG who had no family history of sudden death were evaluated. The degrees of ST segment elevation and conduction delay on signal-averaged ECG (SAECG) before and after pilsicainide were evaluated in all 11 patients. VF inducibility by ventricular electrical stimulation also was evaluated in 8 of 11 patients. Patients were followed for a period of 9 to 84 months (mean 42.5 ± 21.6). The J point level was increased (V1: 0.19 ± 0.09 mV to 0.36 ± 0.23 mV; V2: 0.31 ± 0.12 mV to 0.67 ± 0.35 mV) by pilsicainide. Conduction delay was increased (total QRS: 112.2 ± 6.3 msec to 131.7 ± 6.3 msec; under 40 μV: 42.0 ± 8.5 msec to 52.7 ± 12.7 msec; last 40 msec: 17.4 ± 5.9 μV to 10.4 ± 6.1 μV) on SAECG by pilsicainide. VF was induced in only 1 of 8 patients. None of the patients had syncope or sudden death during a mean follow-up of 42.5 ± 21.6 months. Conclusion: This study suggests that asymptomatic patients with Brugada-type ECG who have no family history of sudden death have a relatively benign clinical course.

Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalJournal of Cardiovascular Electrophysiology
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 1 2001

Keywords

  • Asymptomatic Brugada syndrome
  • Brugada syndrome
  • Pilsicainide
  • Signal-averaged electrocardiography
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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