Relatively benign clinical course in asymptomatic patients with Brugada-type electrocardiogram without family history of sudden death

Shiho Takenaka, Kengo Fukushima Kusano, Kenichi Hisamatsu, Satoshi Nagase, Kazufumi Nakamura, Hiroshi Morita, Hiromi Matsubara, Tetsuro Emori, Tohru Ohe

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Introduction: The incidence of sudden death or ventricular fibrillation (VF) in asymptomatic Brugada syndrome patients with a family history of sudden death is reported to be very high. However, there are few reports on the prognosis of asymptomatic Brugada syndrome patients without a family history of sudden death. Methods and Results: Eleven patients (all male; mean age 40.5 ± 9.6 years, range 26 to 56) with asymptomatic Brugada-type ECG who had no family history of sudden death were evaluated. The degrees of ST segment elevation and conduction delay on signal-averaged ECG (SAECG) before and after pilsicainide were evaluated in all 11 patients. VF inducibility by ventricular electrical stimulation also was evaluated in 8 of 11 patients. Patients were followed for a period of 9 to 84 months (mean 42.5 ± 21.6). The J point level was increased (V1: 0.19 ± 0.09 mV to 0.36 ± 0.23 mV; V2: 0.31 ± 0.12 mV to 0.67 ± 0.35 mV) by pilsicainide. Conduction delay was increased (total QRS: 112.2 ± 6.3 msec to 131.7 ± 6.3 msec; under 40 μV: 42.0 ± 8.5 msec to 52.7 ± 12.7 msec; last 40 msec: 17.4 ± 5.9 μV to 10.4 ± 6.1 μV) on SAECG by pilsicainide. VF was induced in only 1 of 8 patients. None of the patients had syncope or sudden death during a mean follow-up of 42.5 ± 21.6 months. Conclusion: This study suggests that asymptomatic patients with Brugada-type ECG who have no family history of sudden death have a relatively benign clinical course.

Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalJournal of Cardiovascular Electrophysiology
Volume12
Issue number1
Publication statusPublished - 2001

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Sudden Death
Electrocardiography
Ventricular Fibrillation
Brugada Syndrome
Syncope
Electric Stimulation
Incidence

Keywords

  • Asymptomatic Brugada syndrome
  • Brugada syndrome
  • Pilsicainide
  • Signal-averaged electrocardiography
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Relatively benign clinical course in asymptomatic patients with Brugada-type electrocardiogram without family history of sudden death. / Takenaka, Shiho; Kusano, Kengo Fukushima; Hisamatsu, Kenichi; Nagase, Satoshi; Nakamura, Kazufumi; Morita, Hiroshi; Matsubara, Hiromi; Emori, Tetsuro; Ohe, Tohru.

In: Journal of Cardiovascular Electrophysiology, Vol. 12, No. 1, 2001, p. 2-6.

Research output: Contribution to journalArticle

Takenaka, Shiho ; Kusano, Kengo Fukushima ; Hisamatsu, Kenichi ; Nagase, Satoshi ; Nakamura, Kazufumi ; Morita, Hiroshi ; Matsubara, Hiromi ; Emori, Tetsuro ; Ohe, Tohru. / Relatively benign clinical course in asymptomatic patients with Brugada-type electrocardiogram without family history of sudden death. In: Journal of Cardiovascular Electrophysiology. 2001 ; Vol. 12, No. 1. pp. 2-6.
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T1 - Relatively benign clinical course in asymptomatic patients with Brugada-type electrocardiogram without family history of sudden death

AU - Takenaka, Shiho

AU - Kusano, Kengo Fukushima

AU - Hisamatsu, Kenichi

AU - Nagase, Satoshi

AU - Nakamura, Kazufumi

AU - Morita, Hiroshi

AU - Matsubara, Hiromi

AU - Emori, Tetsuro

AU - Ohe, Tohru

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N2 - Introduction: The incidence of sudden death or ventricular fibrillation (VF) in asymptomatic Brugada syndrome patients with a family history of sudden death is reported to be very high. However, there are few reports on the prognosis of asymptomatic Brugada syndrome patients without a family history of sudden death. Methods and Results: Eleven patients (all male; mean age 40.5 ± 9.6 years, range 26 to 56) with asymptomatic Brugada-type ECG who had no family history of sudden death were evaluated. The degrees of ST segment elevation and conduction delay on signal-averaged ECG (SAECG) before and after pilsicainide were evaluated in all 11 patients. VF inducibility by ventricular electrical stimulation also was evaluated in 8 of 11 patients. Patients were followed for a period of 9 to 84 months (mean 42.5 ± 21.6). The J point level was increased (V1: 0.19 ± 0.09 mV to 0.36 ± 0.23 mV; V2: 0.31 ± 0.12 mV to 0.67 ± 0.35 mV) by pilsicainide. Conduction delay was increased (total QRS: 112.2 ± 6.3 msec to 131.7 ± 6.3 msec; under 40 μV: 42.0 ± 8.5 msec to 52.7 ± 12.7 msec; last 40 msec: 17.4 ± 5.9 μV to 10.4 ± 6.1 μV) on SAECG by pilsicainide. VF was induced in only 1 of 8 patients. None of the patients had syncope or sudden death during a mean follow-up of 42.5 ± 21.6 months. Conclusion: This study suggests that asymptomatic patients with Brugada-type ECG who have no family history of sudden death have a relatively benign clinical course.

AB - Introduction: The incidence of sudden death or ventricular fibrillation (VF) in asymptomatic Brugada syndrome patients with a family history of sudden death is reported to be very high. However, there are few reports on the prognosis of asymptomatic Brugada syndrome patients without a family history of sudden death. Methods and Results: Eleven patients (all male; mean age 40.5 ± 9.6 years, range 26 to 56) with asymptomatic Brugada-type ECG who had no family history of sudden death were evaluated. The degrees of ST segment elevation and conduction delay on signal-averaged ECG (SAECG) before and after pilsicainide were evaluated in all 11 patients. VF inducibility by ventricular electrical stimulation also was evaluated in 8 of 11 patients. Patients were followed for a period of 9 to 84 months (mean 42.5 ± 21.6). The J point level was increased (V1: 0.19 ± 0.09 mV to 0.36 ± 0.23 mV; V2: 0.31 ± 0.12 mV to 0.67 ± 0.35 mV) by pilsicainide. Conduction delay was increased (total QRS: 112.2 ± 6.3 msec to 131.7 ± 6.3 msec; under 40 μV: 42.0 ± 8.5 msec to 52.7 ± 12.7 msec; last 40 msec: 17.4 ± 5.9 μV to 10.4 ± 6.1 μV) on SAECG by pilsicainide. VF was induced in only 1 of 8 patients. None of the patients had syncope or sudden death during a mean follow-up of 42.5 ± 21.6 months. Conclusion: This study suggests that asymptomatic patients with Brugada-type ECG who have no family history of sudden death have a relatively benign clinical course.

KW - Asymptomatic Brugada syndrome

KW - Brugada syndrome

KW - Pilsicainide

KW - Signal-averaged electrocardiography

KW - Ventricular fibrillation

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