Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada syndrome

Using body surface signal-averaged electrocardiography and body surface maps

Kenichi Hisamatsu, Kengo Fukushima Kusano, Hiroshi Morita, Shiho Takenaka, Satoshi Nagase, Kazufumi Nakamura, Tetsuro Emori, Hiromi Matsubara, Hiroshi Mikouchi, Yoshitomo Nishizaki, Tohru Ohe

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Introduction: Repolarization and depolarization abnormalities have been reported to be related to Brugada syndrome. Methods and Results: We evaluated the relationships between repolarization abnormality and depolarization abnormality using 48-lead unipolar signal-averaged electrocardiograms and 87-lead unipolar body surface maps in 15 patients with Brugada-type ECGs. Data were compared with those from healthy control subjects (n = 5) and within subgroups of Brugada syndrome with (n = 8) and without (n = 7) ventricular arrhythmias (VA) induced by programmed electrical stimulation (PES). Eighty-seven-lead body surface maps were recorded, and potential maps were constructed to evaluate elevation of the ST segment 20 ms after the J point. Forty-eight-lead signal-averaged ECGs were recorded, and isochronal maps of duration of the delayed potential (dDP) were constructed to evaluate the dDP in each lead. Potential maps showed that patients with Brugada-type ECG, especially those with VA induced by programmed electrical stimulation, had greater elevation of the ST segment in the right ventricular outflow tract, especially at E5. Isochronal maps of dDP in the Brugada-type ECG group showed that maximum dDP was located at E5 and that the area with long dDP was larger than that in the control subjects. The dDPs at E7, E5, F7, and F5 in the VA-inducible group were significantly longer than those in the VA-noninducible group. These results showed that the location of greater elevation in the ST segment coincided with the location of longer dDP. Conclusion: Repolarization abnormality and depolarization abnormality in the walls of both ventricles, especially in the right ventricular outflow tract, are related to the VA of Brugada syndrome.

Original languageEnglish
Pages (from-to)870-876
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume15
Issue number8
DOIs
Publication statusPublished - Aug 2004

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Brugada Syndrome
Cardiac Arrhythmias
Electrocardiography
Electric Stimulation
Healthy Volunteers
Lead

Keywords

  • Brugada syndrome
  • Depolarization abnormality
  • Repolarization abnormality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada syndrome : Using body surface signal-averaged electrocardiography and body surface maps. / Hisamatsu, Kenichi; Kusano, Kengo Fukushima; Morita, Hiroshi; Takenaka, Shiho; Nagase, Satoshi; Nakamura, Kazufumi; Emori, Tetsuro; Matsubara, Hiromi; Mikouchi, Hiroshi; Nishizaki, Yoshitomo; Ohe, Tohru.

In: Journal of Cardiovascular Electrophysiology, Vol. 15, No. 8, 08.2004, p. 870-876.

Research output: Contribution to journalArticle

Hisamatsu, Kenichi ; Kusano, Kengo Fukushima ; Morita, Hiroshi ; Takenaka, Shiho ; Nagase, Satoshi ; Nakamura, Kazufumi ; Emori, Tetsuro ; Matsubara, Hiromi ; Mikouchi, Hiroshi ; Nishizaki, Yoshitomo ; Ohe, Tohru. / Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada syndrome : Using body surface signal-averaged electrocardiography and body surface maps. In: Journal of Cardiovascular Electrophysiology. 2004 ; Vol. 15, No. 8. pp. 870-876.
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T1 - Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada syndrome

T2 - Using body surface signal-averaged electrocardiography and body surface maps

AU - Hisamatsu, Kenichi

AU - Kusano, Kengo Fukushima

AU - Morita, Hiroshi

AU - Takenaka, Shiho

AU - Nagase, Satoshi

AU - Nakamura, Kazufumi

AU - Emori, Tetsuro

AU - Matsubara, Hiromi

AU - Mikouchi, Hiroshi

AU - Nishizaki, Yoshitomo

AU - Ohe, Tohru

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N2 - Introduction: Repolarization and depolarization abnormalities have been reported to be related to Brugada syndrome. Methods and Results: We evaluated the relationships between repolarization abnormality and depolarization abnormality using 48-lead unipolar signal-averaged electrocardiograms and 87-lead unipolar body surface maps in 15 patients with Brugada-type ECGs. Data were compared with those from healthy control subjects (n = 5) and within subgroups of Brugada syndrome with (n = 8) and without (n = 7) ventricular arrhythmias (VA) induced by programmed electrical stimulation (PES). Eighty-seven-lead body surface maps were recorded, and potential maps were constructed to evaluate elevation of the ST segment 20 ms after the J point. Forty-eight-lead signal-averaged ECGs were recorded, and isochronal maps of duration of the delayed potential (dDP) were constructed to evaluate the dDP in each lead. Potential maps showed that patients with Brugada-type ECG, especially those with VA induced by programmed electrical stimulation, had greater elevation of the ST segment in the right ventricular outflow tract, especially at E5. Isochronal maps of dDP in the Brugada-type ECG group showed that maximum dDP was located at E5 and that the area with long dDP was larger than that in the control subjects. The dDPs at E7, E5, F7, and F5 in the VA-inducible group were significantly longer than those in the VA-noninducible group. These results showed that the location of greater elevation in the ST segment coincided with the location of longer dDP. Conclusion: Repolarization abnormality and depolarization abnormality in the walls of both ventricles, especially in the right ventricular outflow tract, are related to the VA of Brugada syndrome.

AB - Introduction: Repolarization and depolarization abnormalities have been reported to be related to Brugada syndrome. Methods and Results: We evaluated the relationships between repolarization abnormality and depolarization abnormality using 48-lead unipolar signal-averaged electrocardiograms and 87-lead unipolar body surface maps in 15 patients with Brugada-type ECGs. Data were compared with those from healthy control subjects (n = 5) and within subgroups of Brugada syndrome with (n = 8) and without (n = 7) ventricular arrhythmias (VA) induced by programmed electrical stimulation (PES). Eighty-seven-lead body surface maps were recorded, and potential maps were constructed to evaluate elevation of the ST segment 20 ms after the J point. Forty-eight-lead signal-averaged ECGs were recorded, and isochronal maps of duration of the delayed potential (dDP) were constructed to evaluate the dDP in each lead. Potential maps showed that patients with Brugada-type ECG, especially those with VA induced by programmed electrical stimulation, had greater elevation of the ST segment in the right ventricular outflow tract, especially at E5. Isochronal maps of dDP in the Brugada-type ECG group showed that maximum dDP was located at E5 and that the area with long dDP was larger than that in the control subjects. The dDPs at E7, E5, F7, and F5 in the VA-inducible group were significantly longer than those in the VA-noninducible group. These results showed that the location of greater elevation in the ST segment coincided with the location of longer dDP. Conclusion: Repolarization abnormality and depolarization abnormality in the walls of both ventricles, especially in the right ventricular outflow tract, are related to the VA of Brugada syndrome.

KW - Brugada syndrome

KW - Depolarization abnormality

KW - Repolarization abnormality

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