Abstract
Background: A close relationship between diabetes and chronic periodontitis has been demonstrated. We previously found that Porphyromonas gingivalis with the type II fimA gene is an infectious factor closely associated with the deterioration seen in diabetic periodontitis patients. In the present study, we examined whether other biomarkers are related to the development and deterioration of periodontitis often seen in type 2 diabetic individuals. Methods: A total of 97 type 2 diabetes patients with and without periodontitis were recruited, and their periodontal and diabetic conditions were analyzed. The ratio (%) of teeth with an attachment loss >5 mm among all teeth in each subject was used as an index of periodontal deterioration. Peripheral blood was tested for levels of glycated hemoglobin (HbA1c), advanced glycation end products (AGEs), C-reactive protein (CRP), and cytokines (tumor necrosis factor [TNF]-α and interleukin [IL]-1β). Subgingival plaque samples were also examined for the occurrences of Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia. Results: Serum AGEs were significantly associated with deterioration of periodontitis, whereas no other serum biochemical marker or bacterial occurrence showed a clear relationship with that condition. Conclusion: AGEs may be factors associated with diabetic periodontitis and may be useful as biomarkers that reflect such deterioration.
| Original language | English |
|---|---|
| Pages (from-to) | 15-20 |
| Number of pages | 6 |
| Journal | Journal of Periodontology |
| Volume | 77 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2006 |
| Externally published | Yes |
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Keywords
- Advanced glycation end products
- Chronic periodontitis
- Diabetes
ASJC Scopus subject areas
- Dentistry(all)
Cite this
Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients. / Takeda, Munehiro; Ojima, Miki; Yoshioka, Hideo; Inaba, Hiroaki; Kogo, Mikihiko; Shizukuishi, Satoshi; Nomura, Makoto; Amano, Atsuo.
In: Journal of Periodontology, Vol. 77, No. 1, 01.2006, p. 15-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients
AU - Takeda, Munehiro
AU - Ojima, Miki
AU - Yoshioka, Hideo
AU - Inaba, Hiroaki
AU - Kogo, Mikihiko
AU - Shizukuishi, Satoshi
AU - Nomura, Makoto
AU - Amano, Atsuo
PY - 2006/1
Y1 - 2006/1
N2 - Background: A close relationship between diabetes and chronic periodontitis has been demonstrated. We previously found that Porphyromonas gingivalis with the type II fimA gene is an infectious factor closely associated with the deterioration seen in diabetic periodontitis patients. In the present study, we examined whether other biomarkers are related to the development and deterioration of periodontitis often seen in type 2 diabetic individuals. Methods: A total of 97 type 2 diabetes patients with and without periodontitis were recruited, and their periodontal and diabetic conditions were analyzed. The ratio (%) of teeth with an attachment loss >5 mm among all teeth in each subject was used as an index of periodontal deterioration. Peripheral blood was tested for levels of glycated hemoglobin (HbA1c), advanced glycation end products (AGEs), C-reactive protein (CRP), and cytokines (tumor necrosis factor [TNF]-α and interleukin [IL]-1β). Subgingival plaque samples were also examined for the occurrences of Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia. Results: Serum AGEs were significantly associated with deterioration of periodontitis, whereas no other serum biochemical marker or bacterial occurrence showed a clear relationship with that condition. Conclusion: AGEs may be factors associated with diabetic periodontitis and may be useful as biomarkers that reflect such deterioration.
AB - Background: A close relationship between diabetes and chronic periodontitis has been demonstrated. We previously found that Porphyromonas gingivalis with the type II fimA gene is an infectious factor closely associated with the deterioration seen in diabetic periodontitis patients. In the present study, we examined whether other biomarkers are related to the development and deterioration of periodontitis often seen in type 2 diabetic individuals. Methods: A total of 97 type 2 diabetes patients with and without periodontitis were recruited, and their periodontal and diabetic conditions were analyzed. The ratio (%) of teeth with an attachment loss >5 mm among all teeth in each subject was used as an index of periodontal deterioration. Peripheral blood was tested for levels of glycated hemoglobin (HbA1c), advanced glycation end products (AGEs), C-reactive protein (CRP), and cytokines (tumor necrosis factor [TNF]-α and interleukin [IL]-1β). Subgingival plaque samples were also examined for the occurrences of Actinobacillus actinomycetemcomitans, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia. Results: Serum AGEs were significantly associated with deterioration of periodontitis, whereas no other serum biochemical marker or bacterial occurrence showed a clear relationship with that condition. Conclusion: AGEs may be factors associated with diabetic periodontitis and may be useful as biomarkers that reflect such deterioration.
KW - Advanced glycation end products
KW - Chronic periodontitis
KW - Diabetes
UR - http://www.scopus.com/inward/record.url?scp=33646178330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646178330&partnerID=8YFLogxK
U2 - 10.1902/jop.2006.77.1.15
DO - 10.1902/jop.2006.77.1.15
M3 - Article
C2 - 16579698
AN - SCOPUS:33646178330
VL - 77
SP - 15
EP - 20
JO - Journal of Periodontology
JF - Journal of Periodontology
SN - 0022-3492
IS - 1
ER -