Relationship of particulate matter and ozone with 3-nitrotyrosine in the atmosphere

Tatsuo Ito, Keiki Ogino, Kenjiro Nagaoka, Kei Takemoto

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The prevalence of allergic diseases has increased in the past few decades. Bio-aerosol proteins and their chemical modifications, such as 3-nitrotyrosine (3-NT), in the atmosphere have been attracting attention due to their promotive effects on allergies. 3-NT is generated from the amino acid, tyrosine, through a reaction with ozone (O3) and nitrogen dioxide (NO2). However, the underlying mechanisms have not yet been elucidated in detail. Therefore, we measured 3-NT and evaluated the relationships among 3-NT and various pollutants such as sulfur dioxide (SO2), NOx (NO + NO2), ozone (O3), PM7, total suspended particulate matter (TSP) containing proteins, humidity, and temperature. 3-NT positively correlated with O3, SO2, humidity, and temperature, and negatively correlated with NOx. A multiple regression analysis showed that 3-NT positively associated with O3, humidity, and PM7. O3 positively associated with 3-NT and PM7, and negatively associated with NOx and humidity. These results suggest that 3-NT is generated from PM proteins through a reaction with O3 under high humidity conditions, and that the measurement of 3-NT is important and useful for the research of O3. Environmental data suggest that 3-NT is generated from PM proteins by the reaction of O3 under high humidity.

Original languageEnglish
Pages (from-to)948-952
Number of pages5
JournalEnvironmental Pollution
Publication statusPublished - May 2018


  • 3-Nitrotyrosine
  • NOx
  • Ozone
  • Particulate matter

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis


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