Relationship of microparticles with β2-glycoprotein I and P-selectin positivity to anticardiolipin antibodies in immune thrombocytopenic purpura

S. Nomura, M. Yanabu, T. Miyake, Y. Miyazaki, H. Kido, H. Kagawa, S. Fukuhara, Y. Komiyama, Eiji Matsuura, T. Koike

Research output: Contribution to journalArticle

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Abstract

We investigated the association of β2-glycoprotein I and P-selectin with platelet-derived microparticles in 48 patients with immune thrombocytopenic purpura and 20 normal controls using two-color flow cytometric analysis. In addition, anticardiolipin antibodies were detected by an enzyme-linked immunosorbent assay. Platelet microparticles from the patients showed a higher positivity for β2-glycoprotein I than those from the normal controls (23.1±15.4% vs. 5.3±3.1%, p2-glycoprotein I positivity was significantly higher than in the 30 patients with less than 20% P-selectin-positive microparticles (37.1±20.5% vs. 21.5±17.3%, p2-glycoprotein I-positive microparticles than the patients without such antibodies (42.0±22.9% vs. 22.6±18.9%, p2-glycoprotein I and P-selectin. These microparticles may then act to regulate coagulation abnormalities in patients with anticardiolipin antibodies.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalAnnals of Hematology
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 1995
Externally publishedYes

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Anticardiolipin Antibodies
P-Selectin
Idiopathic Thrombocytopenic Purpura
Glycoproteins
Blood Platelets
Color
Enzyme-Linked Immunosorbent Assay
Antibodies

Keywords

  • β-glycoprotein I
  • Anticardiolipin antibody P-selectin
  • Immune thrombocytopenic purpura Microparticle

ASJC Scopus subject areas

  • Hematology

Cite this

Relationship of microparticles with β2-glycoprotein I and P-selectin positivity to anticardiolipin antibodies in immune thrombocytopenic purpura. / Nomura, S.; Yanabu, M.; Miyake, T.; Miyazaki, Y.; Kido, H.; Kagawa, H.; Fukuhara, S.; Komiyama, Y.; Matsuura, Eiji; Koike, T.

In: Annals of Hematology, Vol. 70, No. 1, 01.1995, p. 25-30.

Research output: Contribution to journalArticle

Nomura, S. ; Yanabu, M. ; Miyake, T. ; Miyazaki, Y. ; Kido, H. ; Kagawa, H. ; Fukuhara, S. ; Komiyama, Y. ; Matsuura, Eiji ; Koike, T. / Relationship of microparticles with β2-glycoprotein I and P-selectin positivity to anticardiolipin antibodies in immune thrombocytopenic purpura. In: Annals of Hematology. 1995 ; Vol. 70, No. 1. pp. 25-30.
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