Relationship of microparticles with β2-glycoprotein I and P-selectin positivity to anticardiolipin antibodies in immune thrombocytopenic purpura

S. Nomura, M. Yanabu, T. Miyake, Y. Miyazaki, H. Kido, H. Kagawa, S. Fukuhara, Y. Komiyama, Eiji Matsuura, T. Koike

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Abstract

We investigated the association of β2-glycoprotein I and P-selectin with platelet-derived microparticles in 48 patients with immune thrombocytopenic purpura and 20 normal controls using two-color flow cytometric analysis. In addition, anticardiolipin antibodies were detected by an enzyme-linked immunosorbent assay. Platelet microparticles from the patients showed a higher positivity for β2-glycoprotein I than those from the normal controls (23.1±15.4% vs. 5.3±3.1%, p2-glycoprotein I positivity was significantly higher than in the 30 patients with less than 20% P-selectin-positive microparticles (37.1±20.5% vs. 21.5±17.3%, p2-glycoprotein I-positive microparticles than the patients without such antibodies (42.0±22.9% vs. 22.6±18.9%, p2-glycoprotein I and P-selectin. These microparticles may then act to regulate coagulation abnormalities in patients with anticardiolipin antibodies.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalAnnals of Hematology
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 1995
Externally publishedYes

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Keywords

  • β-glycoprotein I
  • Anticardiolipin antibody P-selectin
  • Immune thrombocytopenic purpura Microparticle

ASJC Scopus subject areas

  • Hematology

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