Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation

Y. Zamami, Y. Kouno, T. Niimura, M. Chuma, T. Imai, M. Mitsui, Toshihiro Koyama, M. Kayano, N. Okada, H. Hamano, M. Goda, M. Imanishi, K. Takechi, Y. Horinouchi, Y. Kondo, H. Yanagawa, Yoshihisa Kitamura, Toshiaki Sendo, Y. Ujike, K. Ishizawa

Research output: Contribution to journalArticle

Abstract

A history of hypertension is a known risk factor for delirium in patients in intensive care units, but the effect of antihypertensive agents on delirium development is unclear. Nicardipine, a calcium channel blocker, is widely used in ICU as a treatment agent for hypertensive emergency. This study investigated the relationship between the administration of nicardipine hydrochloride and delirium development in patients under mechanical ventilation. We conducted a medical chart review of 103 patients, who were divided into two groups according to the use of nicardipine hydrochloride. The prevalence of delirium was compared with respect to factors such as age, sex, laboratory data, and medical history, by multivariate analysis. 21 patients (20.4 %) were treated with nicardipine hydrochloride in 103 patients. The treatment and non-treatment groups differed significantly in age (72 vs. 65 years) and history of high blood pressure (57% vs. 11%). Multivariate analysis revealed that patients in the treatment group developed delirium significantly less often than those in the non-treatment group (19% vs. 48%). These results suggested that treatment of high blood pressure with nicardipine hydrochloride is a possible method for preventing the development of delirium.

Original languageEnglish
Pages (from-to)740-743
Number of pages4
JournalPharmazie
Volume73
Issue number12
DOIs
Publication statusPublished - Jan 1 2018

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Nicardipine
Delirium
Artificial Respiration
Hypertension
Multivariate Analysis
Calcium Channel Blockers
Therapeutics
Antihypertensive Agents
Intensive Care Units
Emergencies

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation. / Zamami, Y.; Kouno, Y.; Niimura, T.; Chuma, M.; Imai, T.; Mitsui, M.; Koyama, Toshihiro; Kayano, M.; Okada, N.; Hamano, H.; Goda, M.; Imanishi, M.; Takechi, K.; Horinouchi, Y.; Kondo, Y.; Yanagawa, H.; Kitamura, Yoshihisa; Sendo, Toshiaki; Ujike, Y.; Ishizawa, K.

In: Pharmazie, Vol. 73, No. 12, 01.01.2018, p. 740-743.

Research output: Contribution to journalArticle

Zamami, Y, Kouno, Y, Niimura, T, Chuma, M, Imai, T, Mitsui, M, Koyama, T, Kayano, M, Okada, N, Hamano, H, Goda, M, Imanishi, M, Takechi, K, Horinouchi, Y, Kondo, Y, Yanagawa, H, Kitamura, Y, Sendo, T, Ujike, Y & Ishizawa, K 2018, 'Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation', Pharmazie, vol. 73, no. 12, pp. 740-743. https://doi.org/10.1691/ph.2018.8711
Zamami, Y. ; Kouno, Y. ; Niimura, T. ; Chuma, M. ; Imai, T. ; Mitsui, M. ; Koyama, Toshihiro ; Kayano, M. ; Okada, N. ; Hamano, H. ; Goda, M. ; Imanishi, M. ; Takechi, K. ; Horinouchi, Y. ; Kondo, Y. ; Yanagawa, H. ; Kitamura, Yoshihisa ; Sendo, Toshiaki ; Ujike, Y. ; Ishizawa, K. / Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation. In: Pharmazie. 2018 ; Vol. 73, No. 12. pp. 740-743.
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