Abstract
Background: Non-alcoholic steatohepatitis (NASH) is a severe state of non-alcoholic fatty liver disease (NAFLD), which is pathologically characterised by steatosis, hepatocyte ballooning, and lobular inflammation. Host-microbial interaction has gained attention as one of the risk factors for NASH. Recently, cnm-gene positive Streptococcus mutans expressing cell surface collagen-binding protein, Cnm (cnm-positive S. mutans), was shown to aggravate NASH in model mice. Here, we assessed the detection rate of cnm-positive S. mutans in oral samples from patients with NASH among NAFLD. Methods: This single hospital cohort study included 41 patients with NAFLD. NASH was diagnosed histologically or by clinical score. The prevalence of cnm-positive S. mutans, oral hygiene and blood tests, including liver enzymes, adipocytokines and inflammatory and fibrosis markers, were assessed in biopsy-proven or clinically suspected NASH among NAFLD. Results: Prevalence of cnm-positive S. mutans was significantly higher in patients with NASH than patients without NASH (OR 3.8; 95% CI 1.02 to 15.5). The cnm-positive S. mutans was related to decreased numbers of naturally remaining teeth and increased type IV collagen 7S level (median (IQR) 10.0 (5.0-17.5) vs 20.0 (5.0-25.0), p=0.06; 5.1 (4.0-7.9) vs 4.4 (3.7-5.3), p=0.13, respectively). Conclusions: Prevalence of cnm-positive S. mutans in the oral cavity could be related to fibrosis of NASH among NAFLD.
| Original language | English |
|---|---|
| Article number | e000329 |
| Journal | BMJ Open Gastroenterology |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 1 2019 |
Fingerprint
Keywords
- bacterial infection
- infectious disease
- nonalcoholic steatohepatitis
ASJC Scopus subject areas
- Gastroenterology
Cite this
Relationship between Streptococcus mutans expressing Cnm in the oral cavity and non-alcoholic steatohepatitis : A pilot study. / Tonomura, Shuichi; Naka, Shuhei; Tabata, Keiko; Hara, Tasuku; Mori, Kojiro; Tanaka, Saiyu; Sumida, Yoshio; Kanemasa, Kazuyuki; Nomura, Ryota; Matsumoto-Nakano, Michiyo; Ihara, Masafumi; Takahashi, Nobuyuki; Nakano, Kazuhiko.
In: BMJ Open Gastroenterology, Vol. 6, No. 1, e000329, 01.10.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between Streptococcus mutans expressing Cnm in the oral cavity and non-alcoholic steatohepatitis
T2 - A pilot study
AU - Tonomura, Shuichi
AU - Naka, Shuhei
AU - Tabata, Keiko
AU - Hara, Tasuku
AU - Mori, Kojiro
AU - Tanaka, Saiyu
AU - Sumida, Yoshio
AU - Kanemasa, Kazuyuki
AU - Nomura, Ryota
AU - Matsumoto-Nakano, Michiyo
AU - Ihara, Masafumi
AU - Takahashi, Nobuyuki
AU - Nakano, Kazuhiko
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: Non-alcoholic steatohepatitis (NASH) is a severe state of non-alcoholic fatty liver disease (NAFLD), which is pathologically characterised by steatosis, hepatocyte ballooning, and lobular inflammation. Host-microbial interaction has gained attention as one of the risk factors for NASH. Recently, cnm-gene positive Streptococcus mutans expressing cell surface collagen-binding protein, Cnm (cnm-positive S. mutans), was shown to aggravate NASH in model mice. Here, we assessed the detection rate of cnm-positive S. mutans in oral samples from patients with NASH among NAFLD. Methods: This single hospital cohort study included 41 patients with NAFLD. NASH was diagnosed histologically or by clinical score. The prevalence of cnm-positive S. mutans, oral hygiene and blood tests, including liver enzymes, adipocytokines and inflammatory and fibrosis markers, were assessed in biopsy-proven or clinically suspected NASH among NAFLD. Results: Prevalence of cnm-positive S. mutans was significantly higher in patients with NASH than patients without NASH (OR 3.8; 95% CI 1.02 to 15.5). The cnm-positive S. mutans was related to decreased numbers of naturally remaining teeth and increased type IV collagen 7S level (median (IQR) 10.0 (5.0-17.5) vs 20.0 (5.0-25.0), p=0.06; 5.1 (4.0-7.9) vs 4.4 (3.7-5.3), p=0.13, respectively). Conclusions: Prevalence of cnm-positive S. mutans in the oral cavity could be related to fibrosis of NASH among NAFLD.
AB - Background: Non-alcoholic steatohepatitis (NASH) is a severe state of non-alcoholic fatty liver disease (NAFLD), which is pathologically characterised by steatosis, hepatocyte ballooning, and lobular inflammation. Host-microbial interaction has gained attention as one of the risk factors for NASH. Recently, cnm-gene positive Streptococcus mutans expressing cell surface collagen-binding protein, Cnm (cnm-positive S. mutans), was shown to aggravate NASH in model mice. Here, we assessed the detection rate of cnm-positive S. mutans in oral samples from patients with NASH among NAFLD. Methods: This single hospital cohort study included 41 patients with NAFLD. NASH was diagnosed histologically or by clinical score. The prevalence of cnm-positive S. mutans, oral hygiene and blood tests, including liver enzymes, adipocytokines and inflammatory and fibrosis markers, were assessed in biopsy-proven or clinically suspected NASH among NAFLD. Results: Prevalence of cnm-positive S. mutans was significantly higher in patients with NASH than patients without NASH (OR 3.8; 95% CI 1.02 to 15.5). The cnm-positive S. mutans was related to decreased numbers of naturally remaining teeth and increased type IV collagen 7S level (median (IQR) 10.0 (5.0-17.5) vs 20.0 (5.0-25.0), p=0.06; 5.1 (4.0-7.9) vs 4.4 (3.7-5.3), p=0.13, respectively). Conclusions: Prevalence of cnm-positive S. mutans in the oral cavity could be related to fibrosis of NASH among NAFLD.
KW - bacterial infection
KW - infectious disease
KW - nonalcoholic steatohepatitis
UR - http://www.scopus.com/inward/record.url?scp=85073249984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073249984&partnerID=8YFLogxK
U2 - 10.1136/bmjgast-2019-000329
DO - 10.1136/bmjgast-2019-000329
M3 - Article
AN - SCOPUS:85073249984
VL - 6
JO - BMJ Open Gastroenterology
JF - BMJ Open Gastroenterology
SN - 2054-4774
IS - 1
M1 - e000329
ER -