Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma

Keiki Ogino, Yasushi Obase, Tatsuo Ito, Masaki Fujimura, Eri Eguchi, Masayuki Kubo, Kenjiro Nagaoka, Hiroyuki Nakamura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The relationship between serum arginase I and serum l-arginine or fractional exhaled nitric oxide (FENO) was evaluated cross-sectionally in asthmatic patients. No sex difference was observed in the serum mean levels of arginase I and l-arginine or FENO. Arginase I and FENO were higher in patients 60 or younger years than in those over 60 years. Asthmatic patients were divided into three groups: no steroid therapy, inhalation steroid therapy, and oral steroid therapy. Arginase I, FENO and high-sensitivity-C-reactive protein (hs-CRP) were significantly lower in the inhalation steroid therapy group than in the no steroid therapy group. Correlations were observed between arginase I and FENO, l-arginine, hs-CRP, WBC, and age, and also between FENO and IgE, WBC, and age. A logistic regression analysis revealed the positive association of arginase I with FENO, and the negative association of l-arginine. FENO was positively associated with arginase I and IgE. These results indicated that serum arginase I might influence serum levels of l-arginine and FENO, and that IgE might influence FENO in asthmatic patients.

Original languageEnglish
Pages (from-to)1165-1172
Number of pages8
JournalFree Radical Research
Issue number11
Publication statusPublished - Nov 30 2016


  • Arginase I
  • clinical study
  • fractional exhaled nitric oxide (FENO)
  • l-arginine

ASJC Scopus subject areas

  • Biochemistry


Dive into the research topics of 'Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma'. Together they form a unique fingerprint.

Cite this