Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer: A Retrospective Cohort Study

Hirofumi Mizuno, Hisataka Miyai, Aya Yokoi, Terumasa Kobayashi, Chiaki Inabu, Takayuki Maruyama, Daisuke Ekuni, Nobuyoshi Mizukawa, Shin Kariya, Kazunori Nishizaki, Yoshihiro Kimata, Manabu Morita

Research output: Contribution to journalArticle

Abstract

BACKGROUND/AIM: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. PATIENTS AND METHODS: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. RESULTS: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). CONCLUSION: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalIn vivo (Athens, Greece)
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • concurrent chemoradiotherapy
  • creatinine clearance
  • Head and neck cancer
  • oral mucositis
  • renal dysfunction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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