Abstract
BACKGROUND/AIM: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. PATIENTS AND METHODS: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. RESULTS: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). CONCLUSION: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.
| Original language | English |
|---|---|
| Pages (from-to) | 183-189 |
| Number of pages | 7 |
| Journal | In vivo (Athens, Greece) |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- concurrent chemoradiotherapy
- creatinine clearance
- Head and neck cancer
- oral mucositis
- renal dysfunction
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology
Cite this
Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer : A Retrospective Cohort Study. / Mizuno, Hirofumi; Miyai, Hisataka; Yokoi, Aya; Kobayashi, Terumasa; Inabu, Chiaki; Maruyama, Takayuki; Ekuni, Daisuke; Mizukawa, Nobuyoshi; Kariya, Shin; Nishizaki, Kazunori; Kimata, Yoshihiro; Morita, Manabu.
In: In vivo (Athens, Greece), Vol. 33, No. 1, 01.01.2019, p. 183-189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer
T2 - A Retrospective Cohort Study
AU - Mizuno, Hirofumi
AU - Miyai, Hisataka
AU - Yokoi, Aya
AU - Kobayashi, Terumasa
AU - Inabu, Chiaki
AU - Maruyama, Takayuki
AU - Ekuni, Daisuke
AU - Mizukawa, Nobuyoshi
AU - Kariya, Shin
AU - Nishizaki, Kazunori
AU - Kimata, Yoshihiro
AU - Morita, Manabu
PY - 2019/1/1
Y1 - 2019/1/1
N2 - BACKGROUND/AIM: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. PATIENTS AND METHODS: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. RESULTS: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). CONCLUSION: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.
AB - BACKGROUND/AIM: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. PATIENTS AND METHODS: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. RESULTS: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). CONCLUSION: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.
KW - concurrent chemoradiotherapy
KW - creatinine clearance
KW - Head and neck cancer
KW - oral mucositis
KW - renal dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85059240176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059240176&partnerID=8YFLogxK
U2 - 10.21873/invivo.11457
DO - 10.21873/invivo.11457
M3 - Article
C2 - 30587621
AN - SCOPUS:85059240176
VL - 33
SP - 183
EP - 189
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 1
ER -