Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma

Tomoko Naito, Keiji Yoshikawa, Shiro Mizoue, Mami Nanno, Tairo Kimura, Hirotaka Suzumura, Fumio Shiraga

Research output: Contribution to journalArticle

15 Citations (Scopus)


Purpose: To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. Patients and methods: The subjects of the study were patients undergoing treatment for POAG or NTG who had performed visual field tests at least ten times with a Humphrey field analyzer (Swedish interactive thresholding algorithm standard, C30-2 program). The progression of visual field defects was defined by a significantly negative value of the mean deviation slope at the final visual field test during the follow-up period. The relationships between the progression of visual field defects and IOP, as well as other clinical factors, were retrospectively analyzed. Results: A total of 156 eyes of 156 patients were included in the analysis. Significant progression of visual field defects was observed in 70 eyes of 70 patients (44.9%), while no significant progression was evident in 86 eyes of 86 patients (55.1%). The eyes with visual field defect progression had significantly lower baseline IOP (P

Original languageEnglish
Pages (from-to)1373-1378
Number of pages6
JournalClinical Ophthalmology
Publication statusPublished - Jul 23 2015



  • Intraocular pressure
  • MD slope
  • Normal-tension glaucoma
  • Primary open-angle glaucoma
  • Progression of visual field defects

ASJC Scopus subject areas

  • Ophthalmology

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