Relationship between Prehypertension/Hypertension and Periodontal Disease

A Prospective Cohort Study

Yuya Kawabata, Daisuke Ekuni, Hisataka Miyai, Kota Kataoka, Mayu Yamane, Shinsuke Mizutani, Koichiro Irie, Tetsuji Azuma, Takaaki Tomofuji, Yoshiaki Iwasaki, Manabu Morita

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND Most cross-sectional studies have found a significant positive relationship between periodontal disease and prehypertension/hypertension. However, these studies had limitations and there are few prospective cohort studies in young adults. The purpose of this prospective cohort study was to investigate whether periodontal disease was related to prehypertension/hypertension in Japanese university students. METHODS Students (n = 2,588), who underwent health examinations before entering university and before graduation, were included in the analysis. The association between periodontal disease such as the percentage of bleeding on probing (BOP) and community periodontal index (CPI) scores, and change in blood pressure status was determined. RESULTS At the reexamination, the numbers of participants with prehypertension (systolic blood pressure 120-139mm Hg or diastolic blood pressure 80-89mm Hg) and hypertension (≥140/90mm Hg) were 882 (34.1%) and 109 (4.2%), respectively. In a logistic regression model, the risk of hypertension was significantly associated with male (odds ratio (OR): 6.31; 95% confidence interval (CI): 2.63-15.13; P <0.001), no habitual physical activity at baseline (OR: 2.90; 95% CI: 1.56-5.38; P <0.01) and periodontal disease defined as the presence of both probing pocket depth (PPD) ≥ 4mm and BOP ≥ 30% at baseline (OR: 2.74; 95% CI: 1.19-6.29; P = 0.02) in participants with prehypertension at baseline. On the other hand, the risk of prehypertension was not associated with presence of periodontal disease (OR: 0.93; 95% CI: 0.51-1.70; P = 0.82). CONCLUSION In the short-term prospective cohort study, a significant association between presence of periodontal disease and hypertension was observed in Japanese university students.

Original languageEnglish
Pages (from-to)388-396
Number of pages9
JournalAmerican Journal of Hypertension
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Prehypertension
Periodontal Diseases
Cohort Studies
Prospective Studies
Hypertension
Blood Pressure
Odds Ratio
Confidence Intervals
Students
Logistic Models
Hemorrhage
Periodontal Index
Young Adult
Cross-Sectional Studies
Exercise
Health

Keywords

  • blood pressure
  • cohort studies
  • hypertension
  • periodontal disease
  • university students

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Relationship between Prehypertension/Hypertension and Periodontal Disease : A Prospective Cohort Study. / Kawabata, Yuya; Ekuni, Daisuke; Miyai, Hisataka; Kataoka, Kota; Yamane, Mayu; Mizutani, Shinsuke; Irie, Koichiro; Azuma, Tetsuji; Tomofuji, Takaaki; Iwasaki, Yoshiaki; Morita, Manabu.

In: American Journal of Hypertension, Vol. 29, No. 3, 01.03.2016, p. 388-396.

Research output: Contribution to journalArticle

Kawabata, Yuya ; Ekuni, Daisuke ; Miyai, Hisataka ; Kataoka, Kota ; Yamane, Mayu ; Mizutani, Shinsuke ; Irie, Koichiro ; Azuma, Tetsuji ; Tomofuji, Takaaki ; Iwasaki, Yoshiaki ; Morita, Manabu. / Relationship between Prehypertension/Hypertension and Periodontal Disease : A Prospective Cohort Study. In: American Journal of Hypertension. 2016 ; Vol. 29, No. 3. pp. 388-396.
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abstract = "BACKGROUND Most cross-sectional studies have found a significant positive relationship between periodontal disease and prehypertension/hypertension. However, these studies had limitations and there are few prospective cohort studies in young adults. The purpose of this prospective cohort study was to investigate whether periodontal disease was related to prehypertension/hypertension in Japanese university students. METHODS Students (n = 2,588), who underwent health examinations before entering university and before graduation, were included in the analysis. The association between periodontal disease such as the percentage of bleeding on probing (BOP) and community periodontal index (CPI) scores, and change in blood pressure status was determined. RESULTS At the reexamination, the numbers of participants with prehypertension (systolic blood pressure 120-139mm Hg or diastolic blood pressure 80-89mm Hg) and hypertension (≥140/90mm Hg) were 882 (34.1{\%}) and 109 (4.2{\%}), respectively. In a logistic regression model, the risk of hypertension was significantly associated with male (odds ratio (OR): 6.31; 95{\%} confidence interval (CI): 2.63-15.13; P <0.001), no habitual physical activity at baseline (OR: 2.90; 95{\%} CI: 1.56-5.38; P <0.01) and periodontal disease defined as the presence of both probing pocket depth (PPD) ≥ 4mm and BOP ≥ 30{\%} at baseline (OR: 2.74; 95{\%} CI: 1.19-6.29; P = 0.02) in participants with prehypertension at baseline. On the other hand, the risk of prehypertension was not associated with presence of periodontal disease (OR: 0.93; 95{\%} CI: 0.51-1.70; P = 0.82). CONCLUSION In the short-term prospective cohort study, a significant association between presence of periodontal disease and hypertension was observed in Japanese university students.",
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AU - Kawabata, Yuya

AU - Ekuni, Daisuke

AU - Miyai, Hisataka

AU - Kataoka, Kota

AU - Yamane, Mayu

AU - Mizutani, Shinsuke

AU - Irie, Koichiro

AU - Azuma, Tetsuji

AU - Tomofuji, Takaaki

AU - Iwasaki, Yoshiaki

AU - Morita, Manabu

PY - 2016/3/1

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N2 - BACKGROUND Most cross-sectional studies have found a significant positive relationship between periodontal disease and prehypertension/hypertension. However, these studies had limitations and there are few prospective cohort studies in young adults. The purpose of this prospective cohort study was to investigate whether periodontal disease was related to prehypertension/hypertension in Japanese university students. METHODS Students (n = 2,588), who underwent health examinations before entering university and before graduation, were included in the analysis. The association between periodontal disease such as the percentage of bleeding on probing (BOP) and community periodontal index (CPI) scores, and change in blood pressure status was determined. RESULTS At the reexamination, the numbers of participants with prehypertension (systolic blood pressure 120-139mm Hg or diastolic blood pressure 80-89mm Hg) and hypertension (≥140/90mm Hg) were 882 (34.1%) and 109 (4.2%), respectively. In a logistic regression model, the risk of hypertension was significantly associated with male (odds ratio (OR): 6.31; 95% confidence interval (CI): 2.63-15.13; P <0.001), no habitual physical activity at baseline (OR: 2.90; 95% CI: 1.56-5.38; P <0.01) and periodontal disease defined as the presence of both probing pocket depth (PPD) ≥ 4mm and BOP ≥ 30% at baseline (OR: 2.74; 95% CI: 1.19-6.29; P = 0.02) in participants with prehypertension at baseline. On the other hand, the risk of prehypertension was not associated with presence of periodontal disease (OR: 0.93; 95% CI: 0.51-1.70; P = 0.82). CONCLUSION In the short-term prospective cohort study, a significant association between presence of periodontal disease and hypertension was observed in Japanese university students.

AB - BACKGROUND Most cross-sectional studies have found a significant positive relationship between periodontal disease and prehypertension/hypertension. However, these studies had limitations and there are few prospective cohort studies in young adults. The purpose of this prospective cohort study was to investigate whether periodontal disease was related to prehypertension/hypertension in Japanese university students. METHODS Students (n = 2,588), who underwent health examinations before entering university and before graduation, were included in the analysis. The association between periodontal disease such as the percentage of bleeding on probing (BOP) and community periodontal index (CPI) scores, and change in blood pressure status was determined. RESULTS At the reexamination, the numbers of participants with prehypertension (systolic blood pressure 120-139mm Hg or diastolic blood pressure 80-89mm Hg) and hypertension (≥140/90mm Hg) were 882 (34.1%) and 109 (4.2%), respectively. In a logistic regression model, the risk of hypertension was significantly associated with male (odds ratio (OR): 6.31; 95% confidence interval (CI): 2.63-15.13; P <0.001), no habitual physical activity at baseline (OR: 2.90; 95% CI: 1.56-5.38; P <0.01) and periodontal disease defined as the presence of both probing pocket depth (PPD) ≥ 4mm and BOP ≥ 30% at baseline (OR: 2.74; 95% CI: 1.19-6.29; P = 0.02) in participants with prehypertension at baseline. On the other hand, the risk of prehypertension was not associated with presence of periodontal disease (OR: 0.93; 95% CI: 0.51-1.70; P = 0.82). CONCLUSION In the short-term prospective cohort study, a significant association between presence of periodontal disease and hypertension was observed in Japanese university students.

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