Relationship between partial carbon dioxide pressure and strong ions in humans: A retrospective study

Satoshi Isoyama; Satoshi Kimura; Hiroshi Morimatsu

Relationship between partial carbon dioxide pressure and strong ions in humans: A retrospective study

Satoshi Isoyama, Satoshi Kimura, Hiroshi Morimatsu

Research output: Contribution to journal › Article › peer-review

Abstract

Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO₂) and each of sodium ion (Na⁺) concentrations, chloride ion (Cl^-) concentrations and their difference (SID_Na-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO₂ and SID_Na-Cl was defined as the primary outcome. The associations between pCO₂ and [Cl^-], [Na⁺] and other strong ions were secondary outcomes. pCO₂ was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SID_Na-Cl, [Cl^-], and [Na⁺] among all categorized pCO₂ bands. The respective pCO₂ SID_Na-Cl, [Cl^-], and [Na⁺] correlation coefficients were 0.48,-0.31, and 0.08. SID_Na-Cl increased and [Cl^-] decreased with pCO₂, with little relationship between pCO₂ and [Na⁺] across subsets. In conclusion, we found relatively strong correlations between pCO₂ and SID_Na-Cl in the multiple blood gas datasets examined. Correlations between pCO₂ and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data.

Original language	English
Pages (from-to)	319-325
Number of pages	7
Journal	Acta medica Okayama
Volume	74
Issue number	4
Publication status	Published - 2020

Keywords

Acid-base phenomena
Chlorine ion
Partial carbon dioxide pressure
Stewart approach
Strong ion difference

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Relationship between partial carbon dioxide pressure and strong ions in humans: A retrospective study",

abstract = "Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl-) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl-], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl-], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl-], and [Na+] correlation coefficients were 0.48,-0.31, and 0.08. SIDNa-Cl increased and [Cl-] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data.",

keywords = "Acid-base phenomena, Chlorine ion, Partial carbon dioxide pressure, Stewart approach, Strong ion difference",

author = "Satoshi Isoyama and Satoshi Kimura and Hiroshi Morimatsu",

note = "Publisher Copyright: {\textcopyright} 2020 by Okayama University Medical School.",

year = "2020",

language = "English",

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journal = "Acta Medica Okayama",

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T2 - A retrospective study

AU - Isoyama, Satoshi

AU - Kimura, Satoshi

AU - Morimatsu, Hiroshi

PY - 2020

Y1 - 2020

N2 - Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl-) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl-], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl-], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl-], and [Na+] correlation coefficients were 0.48,-0.31, and 0.08. SIDNa-Cl increased and [Cl-] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data.

AB - Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl-) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl-], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl-], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl-], and [Na+] correlation coefficients were 0.48,-0.31, and 0.08. SIDNa-Cl increased and [Cl-] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data.

KW - Acid-base phenomena

KW - Chlorine ion

KW - Partial carbon dioxide pressure

KW - Stewart approach

KW - Strong ion difference

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Relationship between partial carbon dioxide pressure and strong ions in humans: A retrospective study

Abstract

Keywords

ASJC Scopus subject areas

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