Relationship between oxidative stress and systolic dysfunction in patients with hypertrophic cardiomyopathy

Kazufumi Nakamura, Kengo Fukushima Kusano, Hiromi Matsubara, Yoichi Nakamura, Aya Miura, Nobuhiro Nishii, Kimikazu Banba, Satoshi Nagase, Katsumasa Miyaji, Hiroshi Morita, Hironori Saito, Tetsuro Emori, Tohru Ohe

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48 Citations (Scopus)

Abstract

Background: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism is not known. We examined whether oxidative stress was elevated in myocardia of HCM patients and whether the levels were correlated with left ventricular dilatation and systolic dysfunction. Methods and Results: Endomyocardial biopsy samples obtained from the right ventricular side of the septum of 31 patients with HCM, and 10 control subjects were studied immunohistochemically for the expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product. Expression of HNE-modified protein was found in all myocardial biopsy samples from patients with HCM. Expression was distinct in the cytosol of cardiomyocytes. The expression levels in patients with HCM were significantly increased compared with those in control subjects (P =. 0005). The expression levels in patients with HCM were correlated with left ventricular end-diastolic diameter (r = 0.483, P =. 0053) and end-systolic diameter (r = 0.500, P =. 0037) determined by echocardiography. The expression levels were inversely correlated with left ventricular ejection fraction determined by left ventriculography (r = -0.640, P =. 0001). Conclusion: Oxidative stress was elevated in myocardia of HCM patients and the levels were correlated with left ventricular dilatation and systolic dysfunction. Oxidative stress is involved in the pathogenesis of heart failure in patients with HCM.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalJournal of Cardiac Failure
Volume11
Issue number2
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Cardiomyopathy
  • Heart failure
  • Lipid peroxides
  • Oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Nakamura, K., Kusano, K. F., Matsubara, H., Nakamura, Y., Miura, A., Nishii, N., Banba, K., Nagase, S., Miyaji, K., Morita, H., Saito, H., Emori, T., & Ohe, T. (2005). Relationship between oxidative stress and systolic dysfunction in patients with hypertrophic cardiomyopathy. Journal of Cardiac Failure, 11(2), 117-123. https://doi.org/10.1016/j.cardfail.2004.05.005