Relationship between iga nephropathy and porphyromonas gingivalis; red complex of periodontopathic bacterial species

Yasuyuki Nagasawa, Ryota Nomura, Taro Misaki, Seigo Ito, Shuhei Naka, Kaoruko Wato, Mieko Okunaka, Maiko Watabe, Katsuya Fushimi, Kenzo Tsuzuki, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

IgA nephropathy (IgAN) has been considered to have a relationship with infection in the tonsil, because IgAN patients often manifest macro hematuria just after tonsillitis. In terms of oral-area infection, the red complex of periodontal bacteria (Porphyromonas gingivalis (P. gingivalis), Trep-onema denticol (T. denticola) and Tannerella forsythia (T. forsythia)) is important, but the relationship between these bacteria and IgAN remains unknown. In this study, the prevalence of the red complex of periodontal bacteria in tonsil was compared between IgAN and tonsillitis patients. The path-ogenicity of IgAN induced by P. gingivalis was confirmed by the mice model treated with this bac-terium. The prevalence of P. gingivalis and T. forsythia in IgAN patients was significantly higher than that in tonsillitis patients (p < 0.001 and p < 0.05, respectively). A total of 92% of tonsillitis patients were free from red complex bacteria, while only 48% of IgAN patients had any of these bacteria. Nasal administration of P. gingivalis in mice caused mesangial proliferation (p < 0.05 at days 28a nd 42; p < 0.01 at days 14 and 56) and IgA deposition (p < 0.001 at day 42 and 56 after administration). Scanning-electron-microscopic observation revealed that a high-density Electron-Dense Deposit was widely distributed in the mesangial region in the mice kidneys treated with P. gingivalis. These findings suggest that P. gingivalis is involved in the pathogenesis of IgAN.

Original languageEnglish
Article number13022
JournalInternational journal of molecular sciences
Volume22
Issue number23
DOIs
Publication statusPublished - Dec 1 2021

Keywords

  • IgA nephropathy
  • Infection
  • Mouse
  • Oral bacteria
  • Periodontal bacteria
  • Porphy-romonas gingivalis
  • Tonsil

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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