Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma

Tomoko Naito, Keiji Yoshikawa, Shiro Mizoue, Mami Nanno, Tairo Kimura, Hirotaka Suzumura, Ryuji Takeda, Fumio Shiraga

Research output: Contribution to journalArticle

3 Citations (Scopus)


Purpose: To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma. Patients and methods: The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program). The VF progression was defined by a significantly negative MD slope (MD slope worsening) at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed. Results: A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%), while no significant progression was evident in 93 eyes of 93 patients (56.4%). There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran-Armitage trend test). A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224) and four (odds ratio: 3.6, P=0.0008) consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282). The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0.01). Conclusion: This retrospective study has shown that three or more consecutive deterioration of MD value might be a predictor to future significant MD slope worsening in OAG.

Original languageEnglish
Pages (from-to)2217-2222
Number of pages6
JournalClinical Ophthalmology
Publication statusPublished - Nov 26 2015



  • Consecutive deterioration
  • Humphrey field analyzer
  • Mean deviation slope
  • Mean deviation value
  • Normal tension glaucoma
  • Primary open-angle glaucoma
  • Visual field progression

ASJC Scopus subject areas

  • Ophthalmology

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