TY - JOUR
T1 - Relationship between activin A level and infarct size in patients with acute myocardial infarction undergoing successful primary coronary intervention
AU - Miyoshi, Toru
AU - Hirohata, Satoshi
AU - Uesugi, Tadahisa
AU - Hirota, Minoru
AU - Ohnishi, Hiromichi
AU - Nogami, Kunio
AU - Hatanaka, Kunihiko
AU - Ogawa, Hiroko
AU - Usui, Shinichi
AU - Kusachi, Shozo
N1 - Funding Information:
The authors would like to thank Dr. Masayuki Doi, Dr. Akihiko Iwabu, and Dr. Issei Komatsubara for stimulating discussions. This work was supported in part by funding from a grant-in-aid for Scientific Research from the Japan Society for the Promotion of Science (20790531 to T.M and 20390399 to S.H.).
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/3
Y1 - 2009/3
N2 - Background: Activin A, a member of the transforming growth factor-β cytokine family, has been suggested to have a role in inflammation. We examined the serum level of activin A in patients with acute myocardial infarction (AMI) undergoing successful primary percutaneous coronary intervention (PCI). Methods: The subjects were 30 AMI patients, 20 stable angina pectoris (AP) patients and 20 normal subjects. The serum levels of activin A in AMI patients were measured before PCI and on days 1, 2, 7, and 14. Results: Activin A levels before PCI in AMI patients (557 ± 255 pg/ml) showed a significantly higher value than those in AP patients (364 ± 159 pg/ml) and control subjects (316 ± 144 pg/ml). Increased serum activin A level before PCI was decreased on day 2, and then gradually re-elevated on days 7 and 14. The serum activin A level before PCI was correlated with log-transformed peak creatine kinase (CK) as a surrogate of infarct size (r = 0.48, p = 0.008). Stepwise multiple regression analysis demonstrated that the serum activin A level before PCI was an independent predictor of peak CK. Conclusions: The serum activin A level, increased in AMI, was positively correlated with peak CK and CK-MB levels which are measures of infarction size.
AB - Background: Activin A, a member of the transforming growth factor-β cytokine family, has been suggested to have a role in inflammation. We examined the serum level of activin A in patients with acute myocardial infarction (AMI) undergoing successful primary percutaneous coronary intervention (PCI). Methods: The subjects were 30 AMI patients, 20 stable angina pectoris (AP) patients and 20 normal subjects. The serum levels of activin A in AMI patients were measured before PCI and on days 1, 2, 7, and 14. Results: Activin A levels before PCI in AMI patients (557 ± 255 pg/ml) showed a significantly higher value than those in AP patients (364 ± 159 pg/ml) and control subjects (316 ± 144 pg/ml). Increased serum activin A level before PCI was decreased on day 2, and then gradually re-elevated on days 7 and 14. The serum activin A level before PCI was correlated with log-transformed peak creatine kinase (CK) as a surrogate of infarct size (r = 0.48, p = 0.008). Stepwise multiple regression analysis demonstrated that the serum activin A level before PCI was an independent predictor of peak CK. Conclusions: The serum activin A level, increased in AMI, was positively correlated with peak CK and CK-MB levels which are measures of infarction size.
KW - Coronary artery disease
KW - Diagnosis
KW - Immunoassay
KW - Inflammation
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U2 - 10.1016/j.cca.2008.10.027
DO - 10.1016/j.cca.2008.10.027
M3 - Article
C2 - 19028479
AN - SCOPUS:58549091073
VL - 401
SP - 3
EP - 7
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1-2
ER -