Relation of interlobar collaterals to radiological heterogeneity in severe emphysema

T. Higuchi, A. Reed, Takahiro Oto, L. Holsworth, S. Ellis, M. J. Bailey, T. J. Williams, G. I. Snell

Research output: Contribution to journalArticle

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Abstract

Background: A study was undertaken to assess the prevalence of interlobar collateral ventilation in patients with severe emphysema to identify factors that may help to predict patients with significant collateral ventilation. Methods: Between April 2002 and August 2003, ex vivo assessment of the lungs 17 consecutive patients with smoking related severe emphysema was performed. To assess collateral flow, all lobes of explanted specimens were selectively intubated using a wedged cuffed microlaryngeal intubation tube and then manually ventilated using a bagging circuit. Interlobar collateral ventilation was defined as the ability to easily inflate a non-intubated lobe at physiological pressures. Pre-transplant demographic characteristics, physiological data, radiological results, and explant histology were assessed for retrospective relationships with the degree of interlobar collateral ventilation in the explanted lung. Results: A total of 23 lungs were evaluated, 15 of which (66%) had significant collateral interlobar airflow. There were no significant differences in any demographic, physiological, or pathological variables between patients with collateral ventilation and those with no collateral ventilation. However, there was a significant relationship between the presence of interlobar collateral ventilation and radiological scores (p

Original languageEnglish
Pages (from-to)409-413
Number of pages5
JournalThorax
Volume61
Issue number5
DOIs
Publication statusPublished - May 2006
Externally publishedYes

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Emphysema
Ventilation
Lung
Demography
Aptitude
Intubation
Histology
Smoking
Transplants
Pressure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Higuchi, T., Reed, A., Oto, T., Holsworth, L., Ellis, S., Bailey, M. J., ... Snell, G. I. (2006). Relation of interlobar collaterals to radiological heterogeneity in severe emphysema. Thorax, 61(5), 409-413. https://doi.org/10.1136/thx.2005.051219

Relation of interlobar collaterals to radiological heterogeneity in severe emphysema. / Higuchi, T.; Reed, A.; Oto, Takahiro; Holsworth, L.; Ellis, S.; Bailey, M. J.; Williams, T. J.; Snell, G. I.

In: Thorax, Vol. 61, No. 5, 05.2006, p. 409-413.

Research output: Contribution to journalArticle

Higuchi, T, Reed, A, Oto, T, Holsworth, L, Ellis, S, Bailey, MJ, Williams, TJ & Snell, GI 2006, 'Relation of interlobar collaterals to radiological heterogeneity in severe emphysema', Thorax, vol. 61, no. 5, pp. 409-413. https://doi.org/10.1136/thx.2005.051219
Higuchi, T. ; Reed, A. ; Oto, Takahiro ; Holsworth, L. ; Ellis, S. ; Bailey, M. J. ; Williams, T. J. ; Snell, G. I. / Relation of interlobar collaterals to radiological heterogeneity in severe emphysema. In: Thorax. 2006 ; Vol. 61, No. 5. pp. 409-413.
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