Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers

Yuji Hirami, Motoi Aoe, Kazunori Tsukuda, Fumikata Hara, Yu Otani, Ryuichiro Koshimune, Tetsuro Hanabata, Itaru Nagahiro, Yoshifumi Sano, Hiroshi Date, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The role of the epidermal growth factor receptor (EGFR)/Posphorylated-Akt (P-Akt) signaling axis in regulating hypoxia-inducible factor-1α (HIF-1α) expression in vivo is not well understood and is of potential clinical importance since the extent of hypoxia in the tumor environment is thought to be an important determination of resistance to chemotherapy and radiotherapy. We performed the immunohistochemical studies in 80 patients with non-small cell lung cancers to evaluate EGFR, P-Akt, and HIF-1α expression. Significant correlation between P-Akt and HIF-1α (P=0.0006) and marginal correlation between EGFR and P-Akt (P=0.066) were found. P-Akt was shown to be a poor prognostic factor as to patients with lymph node involvement (P=0.031).

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalCancer Letters
Volume214
Issue number2
DOIs
Publication statusPublished - Oct 28 2004

Fingerprint

Hypoxia-Inducible Factor 1
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Radiotherapy
Lymph Nodes
Drug Therapy

Keywords

  • EGFR
  • HIF-1α
  • Immunohistochemistry
  • NSCLC
  • P-Akt

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers. / Hirami, Yuji; Aoe, Motoi; Tsukuda, Kazunori; Hara, Fumikata; Otani, Yu; Koshimune, Ryuichiro; Hanabata, Tetsuro; Nagahiro, Itaru; Sano, Yoshifumi; Date, Hiroshi; Shimizu, Nobuyoshi.

In: Cancer Letters, Vol. 214, No. 2, 28.10.2004, p. 157-164.

Research output: Contribution to journalArticle

Hirami, Y, Aoe, M, Tsukuda, K, Hara, F, Otani, Y, Koshimune, R, Hanabata, T, Nagahiro, I, Sano, Y, Date, H & Shimizu, N 2004, 'Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers', Cancer Letters, vol. 214, no. 2, pp. 157-164. https://doi.org/10.1016/j.canlet.2004.04.028
Hirami, Yuji ; Aoe, Motoi ; Tsukuda, Kazunori ; Hara, Fumikata ; Otani, Yu ; Koshimune, Ryuichiro ; Hanabata, Tetsuro ; Nagahiro, Itaru ; Sano, Yoshifumi ; Date, Hiroshi ; Shimizu, Nobuyoshi. / Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers. In: Cancer Letters. 2004 ; Vol. 214, No. 2. pp. 157-164.
@article{a74fe645bafb4aad8ae1b38a9838e60d,
title = "Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers",
abstract = "The role of the epidermal growth factor receptor (EGFR)/Posphorylated-Akt (P-Akt) signaling axis in regulating hypoxia-inducible factor-1α (HIF-1α) expression in vivo is not well understood and is of potential clinical importance since the extent of hypoxia in the tumor environment is thought to be an important determination of resistance to chemotherapy and radiotherapy. We performed the immunohistochemical studies in 80 patients with non-small cell lung cancers to evaluate EGFR, P-Akt, and HIF-1α expression. Significant correlation between P-Akt and HIF-1α (P=0.0006) and marginal correlation between EGFR and P-Akt (P=0.066) were found. P-Akt was shown to be a poor prognostic factor as to patients with lymph node involvement (P=0.031).",
keywords = "EGFR, HIF-1α, Immunohistochemistry, NSCLC, P-Akt",
author = "Yuji Hirami and Motoi Aoe and Kazunori Tsukuda and Fumikata Hara and Yu Otani and Ryuichiro Koshimune and Tetsuro Hanabata and Itaru Nagahiro and Yoshifumi Sano and Hiroshi Date and Nobuyoshi Shimizu",
year = "2004",
month = "10",
day = "28",
doi = "10.1016/j.canlet.2004.04.028",
language = "English",
volume = "214",
pages = "157--164",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers

AU - Hirami, Yuji

AU - Aoe, Motoi

AU - Tsukuda, Kazunori

AU - Hara, Fumikata

AU - Otani, Yu

AU - Koshimune, Ryuichiro

AU - Hanabata, Tetsuro

AU - Nagahiro, Itaru

AU - Sano, Yoshifumi

AU - Date, Hiroshi

AU - Shimizu, Nobuyoshi

PY - 2004/10/28

Y1 - 2004/10/28

N2 - The role of the epidermal growth factor receptor (EGFR)/Posphorylated-Akt (P-Akt) signaling axis in regulating hypoxia-inducible factor-1α (HIF-1α) expression in vivo is not well understood and is of potential clinical importance since the extent of hypoxia in the tumor environment is thought to be an important determination of resistance to chemotherapy and radiotherapy. We performed the immunohistochemical studies in 80 patients with non-small cell lung cancers to evaluate EGFR, P-Akt, and HIF-1α expression. Significant correlation between P-Akt and HIF-1α (P=0.0006) and marginal correlation between EGFR and P-Akt (P=0.066) were found. P-Akt was shown to be a poor prognostic factor as to patients with lymph node involvement (P=0.031).

AB - The role of the epidermal growth factor receptor (EGFR)/Posphorylated-Akt (P-Akt) signaling axis in regulating hypoxia-inducible factor-1α (HIF-1α) expression in vivo is not well understood and is of potential clinical importance since the extent of hypoxia in the tumor environment is thought to be an important determination of resistance to chemotherapy and radiotherapy. We performed the immunohistochemical studies in 80 patients with non-small cell lung cancers to evaluate EGFR, P-Akt, and HIF-1α expression. Significant correlation between P-Akt and HIF-1α (P=0.0006) and marginal correlation between EGFR and P-Akt (P=0.066) were found. P-Akt was shown to be a poor prognostic factor as to patients with lymph node involvement (P=0.031).

KW - EGFR

KW - HIF-1α

KW - Immunohistochemistry

KW - NSCLC

KW - P-Akt

UR - http://www.scopus.com/inward/record.url?scp=4444305405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444305405&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2004.04.028

DO - 10.1016/j.canlet.2004.04.028

M3 - Article

C2 - 15363541

AN - SCOPUS:4444305405

VL - 214

SP - 157

EP - 164

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -