Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers

Yuji Hirami, Motoi Aoe, Kazunori Tsukuda, Fumikata Hara, Yu Otani, Ryuichiro Koshimune, Tetsuro Hanabata, Itaru Nagahiro, Yoshifumi Sano, Hiroshi Date, Nobuyoshi Shimizu

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Abstract

The role of the epidermal growth factor receptor (EGFR)/Posphorylated-Akt (P-Akt) signaling axis in regulating hypoxia-inducible factor-1α (HIF-1α) expression in vivo is not well understood and is of potential clinical importance since the extent of hypoxia in the tumor environment is thought to be an important determination of resistance to chemotherapy and radiotherapy. We performed the immunohistochemical studies in 80 patients with non-small cell lung cancers to evaluate EGFR, P-Akt, and HIF-1α expression. Significant correlation between P-Akt and HIF-1α (P=0.0006) and marginal correlation between EGFR and P-Akt (P=0.066) were found. P-Akt was shown to be a poor prognostic factor as to patients with lymph node involvement (P=0.031).

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalCancer Letters
Volume214
Issue number2
DOIs
Publication statusPublished - Oct 28 2004

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Keywords

  • EGFR
  • HIF-1α
  • Immunohistochemistry
  • NSCLC
  • P-Akt

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Hirami, Y., Aoe, M., Tsukuda, K., Hara, F., Otani, Y., Koshimune, R., Hanabata, T., Nagahiro, I., Sano, Y., Date, H., & Shimizu, N. (2004). Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers. Cancer Letters, 214(2), 157-164. https://doi.org/10.1016/j.canlet.2004.04.028