Relation of early improvement in coronary flow reserve to late recovery of left ventricular function after β-blocker therapy in patients with idiopathic dilated cardiomyopathy

Kenichi Sugioka, Takeshi Hozumi, Yasuhiko Takemoto, Shoichi Ehara, Keitaro Ogawa, Shinchi Iwata, Hiroki Oe, Yoshiki Matsumura, Ryo Otsuka, Minoru Yoshiyama, Junichi Yoshikawa

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Background: β-Blocker therapy reverses left ventricular (LV) remodeling in patients with idiopathic dilated cardiomyopathy (IDC). Improvement in coronary circulation by β-blocker could play a role in these circumstances. This study investigated the relationship between change in coronary flow reserve (CFR), as a marker of coronary circulation, and subsequent improvement in LV ejection fraction (LVEF) at follow-up during carvedilol therapy in patients with IDC. Methods: Eighteen patients with IDC underwent CFR measurements by transthoracic Doppler echocardiography at baseline and after 1 month of treatment with carvedilol. A follow-up echocardiographic assessment of LVEF was done at 12 ± 6 months of treatment. The patients were classified by the degree of improvement in LVEF in the follow-up study, as group A (LVEF change ≥10%) and group B (LVEF change

Original languageEnglish
JournalAmerican Heart Journal
Issue number6
Publication statusPublished - Jun 2007
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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