Relation of early improvement in coronary flow reserve to late recovery of left ventricular function after β-blocker therapy in patients with idiopathic dilated cardiomyopathy

Kenichi Sugioka, Takeshi Hozumi, Yasuhiko Takemoto, Shoichi Ehara, Keitaro Ogawa, Shinchi Iwata, Hiroki Oe, Yoshiki Matsumura, Ryo Otsuka, Minoru Yoshiyama, Junichi Yoshikawa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: β-Blocker therapy reverses left ventricular (LV) remodeling in patients with idiopathic dilated cardiomyopathy (IDC). Improvement in coronary circulation by β-blocker could play a role in these circumstances. This study investigated the relationship between change in coronary flow reserve (CFR), as a marker of coronary circulation, and subsequent improvement in LV ejection fraction (LVEF) at follow-up during carvedilol therapy in patients with IDC. Methods: Eighteen patients with IDC underwent CFR measurements by transthoracic Doppler echocardiography at baseline and after 1 month of treatment with carvedilol. A follow-up echocardiographic assessment of LVEF was done at 12 ± 6 months of treatment. The patients were classified by the degree of improvement in LVEF in the follow-up study, as group A (LVEF change ≥10%) and group B (LVEF change

Original languageEnglish
JournalAmerican Heart Journal
Volume153
Issue number6
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Fingerprint

Dilated Cardiomyopathy
Left Ventricular Function
Coronary Circulation
Ventricular Remodeling
Doppler Echocardiography
Therapeutics
Stroke Volume
Echocardiography
carvedilol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of early improvement in coronary flow reserve to late recovery of left ventricular function after β-blocker therapy in patients with idiopathic dilated cardiomyopathy. / Sugioka, Kenichi; Hozumi, Takeshi; Takemoto, Yasuhiko; Ehara, Shoichi; Ogawa, Keitaro; Iwata, Shinchi; Oe, Hiroki; Matsumura, Yoshiki; Otsuka, Ryo; Yoshiyama, Minoru; Yoshikawa, Junichi.

In: American Heart Journal, Vol. 153, No. 6, 06.2007.

Research output: Contribution to journalArticle

Sugioka, Kenichi ; Hozumi, Takeshi ; Takemoto, Yasuhiko ; Ehara, Shoichi ; Ogawa, Keitaro ; Iwata, Shinchi ; Oe, Hiroki ; Matsumura, Yoshiki ; Otsuka, Ryo ; Yoshiyama, Minoru ; Yoshikawa, Junichi. / Relation of early improvement in coronary flow reserve to late recovery of left ventricular function after β-blocker therapy in patients with idiopathic dilated cardiomyopathy. In: American Heart Journal. 2007 ; Vol. 153, No. 6.
@article{c057c9bcbd8548e0a19b5200dccf15b5,
title = "Relation of early improvement in coronary flow reserve to late recovery of left ventricular function after β-blocker therapy in patients with idiopathic dilated cardiomyopathy",
abstract = "Background: β-Blocker therapy reverses left ventricular (LV) remodeling in patients with idiopathic dilated cardiomyopathy (IDC). Improvement in coronary circulation by β-blocker could play a role in these circumstances. This study investigated the relationship between change in coronary flow reserve (CFR), as a marker of coronary circulation, and subsequent improvement in LV ejection fraction (LVEF) at follow-up during carvedilol therapy in patients with IDC. Methods: Eighteen patients with IDC underwent CFR measurements by transthoracic Doppler echocardiography at baseline and after 1 month of treatment with carvedilol. A follow-up echocardiographic assessment of LVEF was done at 12 ± 6 months of treatment. The patients were classified by the degree of improvement in LVEF in the follow-up study, as group A (LVEF change ≥10{\%}) and group B (LVEF change",
author = "Kenichi Sugioka and Takeshi Hozumi and Yasuhiko Takemoto and Shoichi Ehara and Keitaro Ogawa and Shinchi Iwata and Hiroki Oe and Yoshiki Matsumura and Ryo Otsuka and Minoru Yoshiyama and Junichi Yoshikawa",
year = "2007",
month = "6",
doi = "10.1016/j.ahj.2007.03.014",
language = "English",
volume = "153",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Relation of early improvement in coronary flow reserve to late recovery of left ventricular function after β-blocker therapy in patients with idiopathic dilated cardiomyopathy

AU - Sugioka, Kenichi

AU - Hozumi, Takeshi

AU - Takemoto, Yasuhiko

AU - Ehara, Shoichi

AU - Ogawa, Keitaro

AU - Iwata, Shinchi

AU - Oe, Hiroki

AU - Matsumura, Yoshiki

AU - Otsuka, Ryo

AU - Yoshiyama, Minoru

AU - Yoshikawa, Junichi

PY - 2007/6

Y1 - 2007/6

N2 - Background: β-Blocker therapy reverses left ventricular (LV) remodeling in patients with idiopathic dilated cardiomyopathy (IDC). Improvement in coronary circulation by β-blocker could play a role in these circumstances. This study investigated the relationship between change in coronary flow reserve (CFR), as a marker of coronary circulation, and subsequent improvement in LV ejection fraction (LVEF) at follow-up during carvedilol therapy in patients with IDC. Methods: Eighteen patients with IDC underwent CFR measurements by transthoracic Doppler echocardiography at baseline and after 1 month of treatment with carvedilol. A follow-up echocardiographic assessment of LVEF was done at 12 ± 6 months of treatment. The patients were classified by the degree of improvement in LVEF in the follow-up study, as group A (LVEF change ≥10%) and group B (LVEF change

AB - Background: β-Blocker therapy reverses left ventricular (LV) remodeling in patients with idiopathic dilated cardiomyopathy (IDC). Improvement in coronary circulation by β-blocker could play a role in these circumstances. This study investigated the relationship between change in coronary flow reserve (CFR), as a marker of coronary circulation, and subsequent improvement in LV ejection fraction (LVEF) at follow-up during carvedilol therapy in patients with IDC. Methods: Eighteen patients with IDC underwent CFR measurements by transthoracic Doppler echocardiography at baseline and after 1 month of treatment with carvedilol. A follow-up echocardiographic assessment of LVEF was done at 12 ± 6 months of treatment. The patients were classified by the degree of improvement in LVEF in the follow-up study, as group A (LVEF change ≥10%) and group B (LVEF change

UR - http://www.scopus.com/inward/record.url?scp=34249338672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249338672&partnerID=8YFLogxK

U2 - 10.1016/j.ahj.2007.03.014

DO - 10.1016/j.ahj.2007.03.014

M3 - Article

VL - 153

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 6

ER -