Abstract
Objective We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications. Methods A total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV). Results eGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p2). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N. Conclusion eGFR was closely associated with peripheral arterial stiffness in Japanese.
| Original language | English |
|---|---|
| Pages (from-to) | 1315-1320 |
| Number of pages | 6 |
| Journal | Internal Medicine |
| Volume | 49 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Brachial-ankle pulse wave velocity (baPWV)
- Creatinine
- Estimated glomerular filtration rate (eGFR)
- Peripheral arterial stiffness
ASJC Scopus subject areas
- Internal Medicine
Cite this
Relation between the estimated glomerular filtration rate and pulse wave velocity in Japanese. / Miyatake, Nobuyuki; Shikata, Kenichi; Makino, Hirofumi; Numata, Takeyuki.
In: Internal Medicine, Vol. 49, No. 14, 2010, p. 1315-1320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relation between the estimated glomerular filtration rate and pulse wave velocity in Japanese
AU - Miyatake, Nobuyuki
AU - Shikata, Kenichi
AU - Makino, Hirofumi
AU - Numata, Takeyuki
PY - 2010
Y1 - 2010
N2 - Objective We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications. Methods A total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV). Results eGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p2). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N. Conclusion eGFR was closely associated with peripheral arterial stiffness in Japanese.
AB - Objective We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications. Methods A total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV). Results eGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p2). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N. Conclusion eGFR was closely associated with peripheral arterial stiffness in Japanese.
KW - Brachial-ankle pulse wave velocity (baPWV)
KW - Creatinine
KW - Estimated glomerular filtration rate (eGFR)
KW - Peripheral arterial stiffness
UR - http://www.scopus.com/inward/record.url?scp=77955008174&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955008174&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.49.3085
DO - 10.2169/internalmedicine.49.3085
M3 - Article
C2 - 20647642
AN - SCOPUS:77955008174
VL - 49
SP - 1315
EP - 1320
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 14
ER -