Relation between the estimated glomerular filtration rate and pulse wave velocity in Japanese

Nobuyuki Miyatake, Kenichi Shikata, Hirofumi Makino, Takeyuki Numata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications. Methods A total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV). Results eGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p<0.0001, women: r=-0.293, p<0.0001). Twenty-six men (5.6%) and 35 women (4.5%) were diagnosed as reduced eGFR (eGFR <60 mL/min/1.73 m2). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N. Conclusion eGFR was closely associated with peripheral arterial stiffness in Japanese.

Original languageEnglish
Pages (from-to)1315-1320
Number of pages6
JournalInternal Medicine
Volume49
Issue number14
DOIs
Publication statusPublished - 2010

Keywords

  • Brachial-ankle pulse wave velocity (baPWV)
  • Creatinine
  • Estimated glomerular filtration rate (eGFR)
  • Peripheral arterial stiffness

ASJC Scopus subject areas

  • Internal Medicine

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