TY - JOUR
T1 - Relation between the estimated glomerular filtration rate and pulse wave velocity in Japanese
AU - Miyatake, Nobuyuki
AU - Shikata, Kenichi
AU - Makino, Hirofumi
AU - Numata, Takeyuki
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Objective We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications. Methods A total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV). Results eGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p<0.0001, women: r=-0.293, p<0.0001). Twenty-six men (5.6%) and 35 women (4.5%) were diagnosed as reduced eGFR (eGFR <60 mL/min/1.73 m2). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N. Conclusion eGFR was closely associated with peripheral arterial stiffness in Japanese.
AB - Objective We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications. Methods A total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV). Results eGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p<0.0001, women: r=-0.293, p<0.0001). Twenty-six men (5.6%) and 35 women (4.5%) were diagnosed as reduced eGFR (eGFR <60 mL/min/1.73 m2). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N. Conclusion eGFR was closely associated with peripheral arterial stiffness in Japanese.
KW - Brachial-ankle pulse wave velocity (baPWV)
KW - Creatinine
KW - Estimated glomerular filtration rate (eGFR)
KW - Peripheral arterial stiffness
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U2 - 10.2169/internalmedicine.49.3085
DO - 10.2169/internalmedicine.49.3085
M3 - Article
C2 - 20647642
AN - SCOPUS:77955008174
VL - 49
SP - 1315
EP - 1320
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 14
ER -