Relation between neonatal jaundice and oncostatin M, hepatocyte growth factor and soluble gp130 levels in umbilical cord

Hideki Nakatsukasa, Hisashi Masuyama, Yoichiro Akahori, Seiji Inoue, Akio Masumoto, Yuji Hiramatsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives. Oncostatin M (OSM), hepatocyte growth factor (HGF) and soluble glycoprotein 130 (sgp130) have been demonstrated to be involved in fetal liver development. In this study, we examined the relation between neonatal jaundice and OSM, gp130 or HGF levels in umbilical cord blood. Design. A cross-sectional study of 160 neonates born at Okayama University Hospital. Setting. Tertiary referral center serving a population of three million. Methods. The serum concentrations of OSM, HGF and sgp130 in umbilical venous cord blood were measured and compared with the clinical records of these neonates. Results. The HGF level was correlated to both gestational week (p=0.007) and birthweight (p=0.015), as well as to total bilirubin on Day 1 (p=0.032). In preterm neonates, the HGF levels were lower in neonates who received phototherapy (photo group) than in those who did not receive phototherapy (non-photo group) (p=0.002). In contrast, in term neonates, OSM levels were lower in the photo group than in the non-photo group (p=0.0003). Conclusions. These findings suggest that the phototherapy requirement for neonatal jaundice may be associated with lower umbilical HGF concentration in preterm neonates and with lower umbilical OSM concentration in term neonates.

Original languageEnglish
Pages (from-to)1322-1328
Number of pages7
JournalActa Obstetricia et Gynecologica Scandinavica
Volume87
Issue number12
DOIs
Publication statusPublished - 2008

Fingerprint

Cytokine Receptor gp130
Oncostatin M
Neonatal Jaundice
Hepatocyte Growth Factor
Umbilical Cord
Phototherapy
Umbilicus
Fetal Blood
Fetal Development
Bilirubin
Tertiary Care Centers
Cross-Sectional Studies
Liver
Serum

Keywords

  • Hepatocyte growth factor
  • Neonatal jaundice
  • Oncostatin M
  • Phototherapy
  • Soluble glycoprotein 130

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Relation between neonatal jaundice and oncostatin M, hepatocyte growth factor and soluble gp130 levels in umbilical cord. / Nakatsukasa, Hideki; Masuyama, Hisashi; Akahori, Yoichiro; Inoue, Seiji; Masumoto, Akio; Hiramatsu, Yuji.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 87, No. 12, 2008, p. 1322-1328.

Research output: Contribution to journalArticle

Nakatsukasa, Hideki ; Masuyama, Hisashi ; Akahori, Yoichiro ; Inoue, Seiji ; Masumoto, Akio ; Hiramatsu, Yuji. / Relation between neonatal jaundice and oncostatin M, hepatocyte growth factor and soluble gp130 levels in umbilical cord. In: Acta Obstetricia et Gynecologica Scandinavica. 2008 ; Vol. 87, No. 12. pp. 1322-1328.
@article{f02804fe5bf4493db801a5bffcefe8c5,
title = "Relation between neonatal jaundice and oncostatin M, hepatocyte growth factor and soluble gp130 levels in umbilical cord",
abstract = "Objectives. Oncostatin M (OSM), hepatocyte growth factor (HGF) and soluble glycoprotein 130 (sgp130) have been demonstrated to be involved in fetal liver development. In this study, we examined the relation between neonatal jaundice and OSM, gp130 or HGF levels in umbilical cord blood. Design. A cross-sectional study of 160 neonates born at Okayama University Hospital. Setting. Tertiary referral center serving a population of three million. Methods. The serum concentrations of OSM, HGF and sgp130 in umbilical venous cord blood were measured and compared with the clinical records of these neonates. Results. The HGF level was correlated to both gestational week (p=0.007) and birthweight (p=0.015), as well as to total bilirubin on Day 1 (p=0.032). In preterm neonates, the HGF levels were lower in neonates who received phototherapy (photo group) than in those who did not receive phototherapy (non-photo group) (p=0.002). In contrast, in term neonates, OSM levels were lower in the photo group than in the non-photo group (p=0.0003). Conclusions. These findings suggest that the phototherapy requirement for neonatal jaundice may be associated with lower umbilical HGF concentration in preterm neonates and with lower umbilical OSM concentration in term neonates.",
keywords = "Hepatocyte growth factor, Neonatal jaundice, Oncostatin M, Phototherapy, Soluble glycoprotein 130",
author = "Hideki Nakatsukasa and Hisashi Masuyama and Yoichiro Akahori and Seiji Inoue and Akio Masumoto and Yuji Hiramatsu",
year = "2008",
doi = "10.1080/00016340802468332",
language = "English",
volume = "87",
pages = "1322--1328",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Relation between neonatal jaundice and oncostatin M, hepatocyte growth factor and soluble gp130 levels in umbilical cord

AU - Nakatsukasa, Hideki

AU - Masuyama, Hisashi

AU - Akahori, Yoichiro

AU - Inoue, Seiji

AU - Masumoto, Akio

AU - Hiramatsu, Yuji

PY - 2008

Y1 - 2008

N2 - Objectives. Oncostatin M (OSM), hepatocyte growth factor (HGF) and soluble glycoprotein 130 (sgp130) have been demonstrated to be involved in fetal liver development. In this study, we examined the relation between neonatal jaundice and OSM, gp130 or HGF levels in umbilical cord blood. Design. A cross-sectional study of 160 neonates born at Okayama University Hospital. Setting. Tertiary referral center serving a population of three million. Methods. The serum concentrations of OSM, HGF and sgp130 in umbilical venous cord blood were measured and compared with the clinical records of these neonates. Results. The HGF level was correlated to both gestational week (p=0.007) and birthweight (p=0.015), as well as to total bilirubin on Day 1 (p=0.032). In preterm neonates, the HGF levels were lower in neonates who received phototherapy (photo group) than in those who did not receive phototherapy (non-photo group) (p=0.002). In contrast, in term neonates, OSM levels were lower in the photo group than in the non-photo group (p=0.0003). Conclusions. These findings suggest that the phototherapy requirement for neonatal jaundice may be associated with lower umbilical HGF concentration in preterm neonates and with lower umbilical OSM concentration in term neonates.

AB - Objectives. Oncostatin M (OSM), hepatocyte growth factor (HGF) and soluble glycoprotein 130 (sgp130) have been demonstrated to be involved in fetal liver development. In this study, we examined the relation between neonatal jaundice and OSM, gp130 or HGF levels in umbilical cord blood. Design. A cross-sectional study of 160 neonates born at Okayama University Hospital. Setting. Tertiary referral center serving a population of three million. Methods. The serum concentrations of OSM, HGF and sgp130 in umbilical venous cord blood were measured and compared with the clinical records of these neonates. Results. The HGF level was correlated to both gestational week (p=0.007) and birthweight (p=0.015), as well as to total bilirubin on Day 1 (p=0.032). In preterm neonates, the HGF levels were lower in neonates who received phototherapy (photo group) than in those who did not receive phototherapy (non-photo group) (p=0.002). In contrast, in term neonates, OSM levels were lower in the photo group than in the non-photo group (p=0.0003). Conclusions. These findings suggest that the phototherapy requirement for neonatal jaundice may be associated with lower umbilical HGF concentration in preterm neonates and with lower umbilical OSM concentration in term neonates.

KW - Hepatocyte growth factor

KW - Neonatal jaundice

KW - Oncostatin M

KW - Phototherapy

KW - Soluble glycoprotein 130

UR - http://www.scopus.com/inward/record.url?scp=57449108565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57449108565&partnerID=8YFLogxK

U2 - 10.1080/00016340802468332

DO - 10.1080/00016340802468332

M3 - Article

VL - 87

SP - 1322

EP - 1328

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 12

ER -