Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations

Ai Yamada, Hiroshi Moritake, Mariko Kinoshita, Daisuke Sawa, Sachiyo Kamimura, Shotaro Iwamoto, Yuka Yamashita, Jiro Inagaki, Takahide Takahashi, Akira Shimada, Megumi Obara, Hiroyuki Nunoi

Research output: Contribution to journalArticle

Abstract

Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15-year-old Japanese boy with inv(16) harboring a low-allelic burden internal tandem duplication of FLT3 (FLT3-ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low-allelic burden FLT3-ITD mutation, although another clone with a KIT mutation occurred 17 months later. Further investigation is necessary to identify AML with inv(16) conferring poor prognosis, to facilitate appropriate treatment with additional drugs, such as dasatinib or gemtuzumab ozogamicin.

Original languageEnglish
JournalPediatrics International
DOIs
Publication statusAccepted/In press - 2016

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Keywords

  • Acute myeloid leukemia
  • Allelic burden
  • FLT3-internal tandem duplication
  • Inv(16)
  • KIT

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Yamada, A., Moritake, H., Kinoshita, M., Sawa, D., Kamimura, S., Iwamoto, S., Yamashita, Y., Inagaki, J., Takahashi, T., Shimada, A., Obara, M., & Nunoi, H. (Accepted/In press). Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations. Pediatrics International. https://doi.org/10.1111/ped.13010