Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations

Ai Yamada, Hiroshi Moritake, Mariko Kinoshita, Daisuke Sawa, Sachiyo Kamimura, Shotaro Iwamoto, Yuka Yamashita, Jiro Inagaki, Takahide Takahashi, Akira Shimada, Megumi Obara, Hiroyuki Nunoi

Research output: Contribution to journalComment/debate

Abstract

Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15-year-old Japanese boy with inv(16) harboring a low-allelic burden internal tandem duplication of FLT3 (FLT3-ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low-allelic burden FLT3-ITD mutation, although another clone with a KIT mutation occurred 17 months later. Further investigation is necessary to identify AML with inv(16) conferring poor prognosis, to facilitate appropriate treatment with additional drugs, such as dasatinib or gemtuzumab ozogamicin.

Original languageEnglish
Pages (from-to)905-908
Number of pages4
JournalPediatrics International
Volume58
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • FLT3-internal tandem duplication
  • KIT
  • acute myeloid leukemia
  • allelic burden
  • inv(16)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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  • Cite this

    Yamada, A., Moritake, H., Kinoshita, M., Sawa, D., Kamimura, S., Iwamoto, S., Yamashita, Y., Inagaki, J., Takahashi, T., Shimada, A., Obara, M., & Nunoi, H. (2016). Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations. Pediatrics International, 58(9), 905-908. https://doi.org/10.1111/ped.13010