Reinfection rate of Helicobacter pylori after eradication treatment

A long-term prospective study in Japan

Susumu Take, Motowo Mizuno, Kuniharu Ishiki, Takayuki Imada, Tetsuji Okuno, Tomowo Yoshida, Kenji Yokota, Keiji Oguma, Masahide Kita, Hiroyuki Okada, Kazuhide Yamamoto

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background We previously reported that the reinfection rate with Helicobacter pylori in Japan was low despite a high prevalence of infection. In the present study, we extended our previous work to more accurately determine the reinfection rate. Methods We enrolled 1625 patients (219 women and 1406 men, mean age 50.8 years) who had received H. pylori eradication therapy. After documentation of eradication, bacterial culture and urea breath test were carried out yearly. H. pylori strains were analyzed by using random amplification of polymorphic DNA fingerprinting. Results A total of 1609 patients were followed for up to 12.5 years (mean 4.7 years); H. pylori became re-positive in 26 patients. In 13 of the 26 patients, H. pylori became positive at the first-year follow up. Stored H. pylori isolates were available for analysis from ten of the 13 patients; four of the isolates were genetically different from the initial strain, but the other six were identical to the initial strain. In the other 13 patients, H. pylori became positive at later follow up (mean 4.8 years; range 1.8-8.0 years). In all of the four of these patients whose isolates could be analyzed, the H. pylori strains were different from the initial strain. Assuming that reinfection occurred in the four patients positive for different strains of H. pylori at the first-year follow up and in the 13 positive at later follow up, the reinfection rate was 0.22% per year. Conclusions When probable recrudescence (H. pylori positivity with identical strains) was excluded, the reinfection rate of H. pylori in this Japanese population was very low, but we note that reinfection can occur over many years.

Original languageEnglish
Pages (from-to)641-646
Number of pages6
JournalJournal of Gastroenterology
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 2012

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Helicobacter pylori
Japan
Prospective Studies
Therapeutics
Breath Tests
DNA Fingerprinting
Documentation
Urea
Recurrence

Keywords

  • Eradication therapy
  • Helicobacter pylori
  • Reinfection rate

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Reinfection rate of Helicobacter pylori after eradication treatment : A long-term prospective study in Japan. / Take, Susumu; Mizuno, Motowo; Ishiki, Kuniharu; Imada, Takayuki; Okuno, Tetsuji; Yoshida, Tomowo; Yokota, Kenji; Oguma, Keiji; Kita, Masahide; Okada, Hiroyuki; Yamamoto, Kazuhide.

In: Journal of Gastroenterology, Vol. 47, No. 6, 06.2012, p. 641-646.

Research output: Contribution to journalArticle

Take, S, Mizuno, M, Ishiki, K, Imada, T, Okuno, T, Yoshida, T, Yokota, K, Oguma, K, Kita, M, Okada, H & Yamamoto, K 2012, 'Reinfection rate of Helicobacter pylori after eradication treatment: A long-term prospective study in Japan', Journal of Gastroenterology, vol. 47, no. 6, pp. 641-646. https://doi.org/10.1007/s00535-012-0536-9
Take, Susumu ; Mizuno, Motowo ; Ishiki, Kuniharu ; Imada, Takayuki ; Okuno, Tetsuji ; Yoshida, Tomowo ; Yokota, Kenji ; Oguma, Keiji ; Kita, Masahide ; Okada, Hiroyuki ; Yamamoto, Kazuhide. / Reinfection rate of Helicobacter pylori after eradication treatment : A long-term prospective study in Japan. In: Journal of Gastroenterology. 2012 ; Vol. 47, No. 6. pp. 641-646.
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abstract = "Background We previously reported that the reinfection rate with Helicobacter pylori in Japan was low despite a high prevalence of infection. In the present study, we extended our previous work to more accurately determine the reinfection rate. Methods We enrolled 1625 patients (219 women and 1406 men, mean age 50.8 years) who had received H. pylori eradication therapy. After documentation of eradication, bacterial culture and urea breath test were carried out yearly. H. pylori strains were analyzed by using random amplification of polymorphic DNA fingerprinting. Results A total of 1609 patients were followed for up to 12.5 years (mean 4.7 years); H. pylori became re-positive in 26 patients. In 13 of the 26 patients, H. pylori became positive at the first-year follow up. Stored H. pylori isolates were available for analysis from ten of the 13 patients; four of the isolates were genetically different from the initial strain, but the other six were identical to the initial strain. In the other 13 patients, H. pylori became positive at later follow up (mean 4.8 years; range 1.8-8.0 years). In all of the four of these patients whose isolates could be analyzed, the H. pylori strains were different from the initial strain. Assuming that reinfection occurred in the four patients positive for different strains of H. pylori at the first-year follow up and in the 13 positive at later follow up, the reinfection rate was 0.22{\%} per year. Conclusions When probable recrudescence (H. pylori positivity with identical strains) was excluded, the reinfection rate of H. pylori in this Japanese population was very low, but we note that reinfection can occur over many years.",
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T2 - A long-term prospective study in Japan

AU - Take, Susumu

AU - Mizuno, Motowo

AU - Ishiki, Kuniharu

AU - Imada, Takayuki

AU - Okuno, Tetsuji

AU - Yoshida, Tomowo

AU - Yokota, Kenji

AU - Oguma, Keiji

AU - Kita, Masahide

AU - Okada, Hiroyuki

AU - Yamamoto, Kazuhide

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N2 - Background We previously reported that the reinfection rate with Helicobacter pylori in Japan was low despite a high prevalence of infection. In the present study, we extended our previous work to more accurately determine the reinfection rate. Methods We enrolled 1625 patients (219 women and 1406 men, mean age 50.8 years) who had received H. pylori eradication therapy. After documentation of eradication, bacterial culture and urea breath test were carried out yearly. H. pylori strains were analyzed by using random amplification of polymorphic DNA fingerprinting. Results A total of 1609 patients were followed for up to 12.5 years (mean 4.7 years); H. pylori became re-positive in 26 patients. In 13 of the 26 patients, H. pylori became positive at the first-year follow up. Stored H. pylori isolates were available for analysis from ten of the 13 patients; four of the isolates were genetically different from the initial strain, but the other six were identical to the initial strain. In the other 13 patients, H. pylori became positive at later follow up (mean 4.8 years; range 1.8-8.0 years). In all of the four of these patients whose isolates could be analyzed, the H. pylori strains were different from the initial strain. Assuming that reinfection occurred in the four patients positive for different strains of H. pylori at the first-year follow up and in the 13 positive at later follow up, the reinfection rate was 0.22% per year. Conclusions When probable recrudescence (H. pylori positivity with identical strains) was excluded, the reinfection rate of H. pylori in this Japanese population was very low, but we note that reinfection can occur over many years.

AB - Background We previously reported that the reinfection rate with Helicobacter pylori in Japan was low despite a high prevalence of infection. In the present study, we extended our previous work to more accurately determine the reinfection rate. Methods We enrolled 1625 patients (219 women and 1406 men, mean age 50.8 years) who had received H. pylori eradication therapy. After documentation of eradication, bacterial culture and urea breath test were carried out yearly. H. pylori strains were analyzed by using random amplification of polymorphic DNA fingerprinting. Results A total of 1609 patients were followed for up to 12.5 years (mean 4.7 years); H. pylori became re-positive in 26 patients. In 13 of the 26 patients, H. pylori became positive at the first-year follow up. Stored H. pylori isolates were available for analysis from ten of the 13 patients; four of the isolates were genetically different from the initial strain, but the other six were identical to the initial strain. In the other 13 patients, H. pylori became positive at later follow up (mean 4.8 years; range 1.8-8.0 years). In all of the four of these patients whose isolates could be analyzed, the H. pylori strains were different from the initial strain. Assuming that reinfection occurred in the four patients positive for different strains of H. pylori at the first-year follow up and in the 13 positive at later follow up, the reinfection rate was 0.22% per year. Conclusions When probable recrudescence (H. pylori positivity with identical strains) was excluded, the reinfection rate of H. pylori in this Japanese population was very low, but we note that reinfection can occur over many years.

KW - Eradication therapy

KW - Helicobacter pylori

KW - Reinfection rate

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