Reinfection rate following effective therapy against Helicobacter pylori infection in Japan

Masayasu Adachi, Motowo Mizuno, Kenji Yokota, Masatsugu Miyoshi, Yasuhiro Nagahara, Toshirou Maga, Kuniharu Ishiki, Tomoki Inaba, Hiroyuki Okada, Keiji Oguma, Takao Tsuji

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background and Aim: In developed countries, reinfection of Helicobacter pylori (H. pylori) after eradication of the bacterium is unusual, while the reinfection rate in developing countries is variable. In this study, we determined the reinfection rate after successful H. pylori eradication in Japan, a country with a high prevalence of H. pylori infection. Methods: After successful eradication, 377 patients were followed up by endoscopy and urea breath test annually. In reinfected patients, H. pylori strains isolated initially and after reinfection were compared by using random amplification of polymorphic DNA fingerprinting. Results: H. pylori became positive in four of 337 patients (1.2%) 1 year after eradication and in two of 133 patients (1.5%) 2 years after eradication. One patient experienced an ulcer relapse 2 years after eradication therapy. Random amplification of polymorphic DNA fingerprinting of the isolated strains from four of the six patients showed two had identical strains (at 1 year) while the other two had different strains (one at 1 year and one at 2 years). When infection in the two patients reinfected with identical strains is considered a recrudescence, the true reinfection rate is

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume17
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Helicobacter Infections
Helicobacter pylori
Japan
DNA Fingerprinting
Therapeutics
Recurrence
Breath Tests
Developed Countries
Developing Countries
Endoscopy
Ulcer
Urea
Bacteria
Infection

Keywords

  • Eradication therapy
  • Helicobacter pylori
  • Reinfection rate

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Reinfection rate following effective therapy against Helicobacter pylori infection in Japan. / Adachi, Masayasu; Mizuno, Motowo; Yokota, Kenji; Miyoshi, Masatsugu; Nagahara, Yasuhiro; Maga, Toshirou; Ishiki, Kuniharu; Inaba, Tomoki; Okada, Hiroyuki; Oguma, Keiji; Tsuji, Takao.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 17, No. 1, 2002, p. 27-31.

Research output: Contribution to journalArticle

Adachi, Masayasu ; Mizuno, Motowo ; Yokota, Kenji ; Miyoshi, Masatsugu ; Nagahara, Yasuhiro ; Maga, Toshirou ; Ishiki, Kuniharu ; Inaba, Tomoki ; Okada, Hiroyuki ; Oguma, Keiji ; Tsuji, Takao. / Reinfection rate following effective therapy against Helicobacter pylori infection in Japan. In: Journal of Gastroenterology and Hepatology (Australia). 2002 ; Vol. 17, No. 1. pp. 27-31.
@article{e808b78c8da54b929f21e2eed3aa775d,
title = "Reinfection rate following effective therapy against Helicobacter pylori infection in Japan",
abstract = "Background and Aim: In developed countries, reinfection of Helicobacter pylori (H. pylori) after eradication of the bacterium is unusual, while the reinfection rate in developing countries is variable. In this study, we determined the reinfection rate after successful H. pylori eradication in Japan, a country with a high prevalence of H. pylori infection. Methods: After successful eradication, 377 patients were followed up by endoscopy and urea breath test annually. In reinfected patients, H. pylori strains isolated initially and after reinfection were compared by using random amplification of polymorphic DNA fingerprinting. Results: H. pylori became positive in four of 337 patients (1.2{\%}) 1 year after eradication and in two of 133 patients (1.5{\%}) 2 years after eradication. One patient experienced an ulcer relapse 2 years after eradication therapy. Random amplification of polymorphic DNA fingerprinting of the isolated strains from four of the six patients showed two had identical strains (at 1 year) while the other two had different strains (one at 1 year and one at 2 years). When infection in the two patients reinfected with identical strains is considered a recrudescence, the true reinfection rate is",
keywords = "Eradication therapy, Helicobacter pylori, Reinfection rate",
author = "Masayasu Adachi and Motowo Mizuno and Kenji Yokota and Masatsugu Miyoshi and Yasuhiro Nagahara and Toshirou Maga and Kuniharu Ishiki and Tomoki Inaba and Hiroyuki Okada and Keiji Oguma and Takao Tsuji",
year = "2002",
doi = "10.1046/j.1440-1746.2002.02666.x",
language = "English",
volume = "17",
pages = "27--31",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Reinfection rate following effective therapy against Helicobacter pylori infection in Japan

AU - Adachi, Masayasu

AU - Mizuno, Motowo

AU - Yokota, Kenji

AU - Miyoshi, Masatsugu

AU - Nagahara, Yasuhiro

AU - Maga, Toshirou

AU - Ishiki, Kuniharu

AU - Inaba, Tomoki

AU - Okada, Hiroyuki

AU - Oguma, Keiji

AU - Tsuji, Takao

PY - 2002

Y1 - 2002

N2 - Background and Aim: In developed countries, reinfection of Helicobacter pylori (H. pylori) after eradication of the bacterium is unusual, while the reinfection rate in developing countries is variable. In this study, we determined the reinfection rate after successful H. pylori eradication in Japan, a country with a high prevalence of H. pylori infection. Methods: After successful eradication, 377 patients were followed up by endoscopy and urea breath test annually. In reinfected patients, H. pylori strains isolated initially and after reinfection were compared by using random amplification of polymorphic DNA fingerprinting. Results: H. pylori became positive in four of 337 patients (1.2%) 1 year after eradication and in two of 133 patients (1.5%) 2 years after eradication. One patient experienced an ulcer relapse 2 years after eradication therapy. Random amplification of polymorphic DNA fingerprinting of the isolated strains from four of the six patients showed two had identical strains (at 1 year) while the other two had different strains (one at 1 year and one at 2 years). When infection in the two patients reinfected with identical strains is considered a recrudescence, the true reinfection rate is

AB - Background and Aim: In developed countries, reinfection of Helicobacter pylori (H. pylori) after eradication of the bacterium is unusual, while the reinfection rate in developing countries is variable. In this study, we determined the reinfection rate after successful H. pylori eradication in Japan, a country with a high prevalence of H. pylori infection. Methods: After successful eradication, 377 patients were followed up by endoscopy and urea breath test annually. In reinfected patients, H. pylori strains isolated initially and after reinfection were compared by using random amplification of polymorphic DNA fingerprinting. Results: H. pylori became positive in four of 337 patients (1.2%) 1 year after eradication and in two of 133 patients (1.5%) 2 years after eradication. One patient experienced an ulcer relapse 2 years after eradication therapy. Random amplification of polymorphic DNA fingerprinting of the isolated strains from four of the six patients showed two had identical strains (at 1 year) while the other two had different strains (one at 1 year and one at 2 years). When infection in the two patients reinfected with identical strains is considered a recrudescence, the true reinfection rate is

KW - Eradication therapy

KW - Helicobacter pylori

KW - Reinfection rate

UR - http://www.scopus.com/inward/record.url?scp=0036223448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036223448&partnerID=8YFLogxK

U2 - 10.1046/j.1440-1746.2002.02666.x

DO - 10.1046/j.1440-1746.2002.02666.x

M3 - Article

VL - 17

SP - 27

EP - 31

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 1

ER -