Regulatory T cells and IL-17-producing cells in graft-versus-host disease

Takanori Teshima, Yoshinobu Maeda, Katsutoshi Ozaki

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Graft-versus-host disease (GvHD), a major complication following allogeneic hematopoietic stem cell transplantation, is mediated by donor-derived T cells. On activation with alloantigens expressed on host antigen-presenting cells, naive CD4 + T cells differentiate into T-helper cell subsets of effector T cells expressing distinct sets of transcriptional factors and cytokines. Classically, acute GvHD was suggested to be predominantly related to Th1 responses. However, we now face a completely different and complex scenario involving possible roles of newly identified Th17 cells as well as Tregs in GvHD. Accumulating data from experimental and clinical studies suggest that the fine balance between Th1, Th2, Th17 and Tregs after transplantation may be an important determinant of the severity, manifestation and tissue distribution of GvHD. Understanding the dynamic process of reciprocal differentiation of regulatory and T-helper cell subsets as well as their interactions will be important in establishing novel strategies for preventing and treating GvHD.

Original languageEnglish
Pages (from-to)833-852
Number of pages20
JournalImmunotherapy
Volume3
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Interleukin-17
Graft vs Host Disease
Regulatory T-Lymphocytes
T-Lymphocyte Subsets
T-Lymphocytes
Th1-Th2 Balance
Th17 Cells
Isoantigens
Hematopoietic Stem Cell Transplantation
Antigen-Presenting Cells
Tissue Distribution
Transplantation
Cytokines
Transplants

Keywords

  • graft-versus-host disease
  • graft-versus-leukemia
  • helper T cell
  • hematopoietic stem cell transplantation
  • immunotherapy
  • regulatory T cell
  • Th17

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

Regulatory T cells and IL-17-producing cells in graft-versus-host disease. / Teshima, Takanori; Maeda, Yoshinobu; Ozaki, Katsutoshi.

In: Immunotherapy, Vol. 3, No. 7, 07.2011, p. 833-852.

Research output: Contribution to journalArticle

Teshima, Takanori ; Maeda, Yoshinobu ; Ozaki, Katsutoshi. / Regulatory T cells and IL-17-producing cells in graft-versus-host disease. In: Immunotherapy. 2011 ; Vol. 3, No. 7. pp. 833-852.
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