Regulatory effects of 1-α, 25-dihydroxyvitamin D3 on inflammatory responses in psoriasis

Masayuki Inoue, Takashi Matsui, Akiko Nishibu, Yoshimichi Nihei, Keiji Iwatsuki, Fumio Kaneko

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Topical application of 1α, 25-dihydroxyvitamin D3 (VD3) is thought to be beneficial in psoriasis because of its action in regulating keratinocyte proliferation and inflammation mediated by various cytokines. We assessed the effect of VD3 on the production levels of interferon (IFN)-γ, interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α in mitogen-stimulated peripheral blood mononuclear cells (PBMC) of psoriatic patients. The results demonstrated that VD3 significantly inhibited IFN-γ, IL-6, and IL-8 levels produced by concanavalin A (Con A)-stimulated PBMC of psoriatic patients in a dose-dependent manner, and reduced mRNA expression for IFN-γ and IL-8. These findings suggest that in addition to the direct anti-proliferation effect on keratinocytes, VD3 may down-regulate the inflammatory cytokine production by infiltrating cells in psoriatic lesions.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalEuropean Journal of Dermatology
Volume8
Issue number1
Publication statusPublished - Jan 1 1998

Keywords

  • 25-dihydroxyvitamin D
  • Interferon-γ
  • Interleukin- 6
  • Interleukin-8
  • Psoriasis
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Dermatology

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    Inoue, M., Matsui, T., Nishibu, A., Nihei, Y., Iwatsuki, K., & Kaneko, F. (1998). Regulatory effects of 1-α, 25-dihydroxyvitamin D3 on inflammatory responses in psoriasis. European Journal of Dermatology, 8(1), 16-20.