Abstract
Vibrio parahaemolyticus is a leading causative agent of seafood-borne gastroenteritis worldwide. Most clinical isolates from patients with diarrhoea possess two sets of genes for the type III secretion system (T3SS) on each chromosome (T3SS1 and T3SS2). T3SS is a protein secretion system that delivers effector proteins directly into eukaryotic cells. The injected effectors modify the normal cell functions by altering or disrupting the normal cell signalling pathways. Of the two sets of T3SS genes present in V.parahaemolyticus, T3SS2 is essential for enterotoxicity in several animal models. Recent studies have elucidated the biological activities of several T3SS2 effectors and their roles in virulence. This review focuses on the regulation of T3SS2 gene expression and T3SS2 effectors that specifically target the actin cytoskeleton.
| Original language | English |
|---|---|
| Pages (from-to) | 183-190 |
| Number of pages | 8 |
| Journal | Cellular Microbiology |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2015 |
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ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology
- Medicine(all)
Cite this
Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton. / Kodama, Toshio; Hiyoshi, Hirotaka; Okada, Ryu; Matsuda, Shigeaki; Goto, Kazuyoshi; Iida, Tetsuya.
In: Cellular Microbiology, Vol. 17, No. 2, 01.02.2015, p. 183-190.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton
AU - Kodama, Toshio
AU - Hiyoshi, Hirotaka
AU - Okada, Ryu
AU - Matsuda, Shigeaki
AU - Goto, Kazuyoshi
AU - Iida, Tetsuya
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Vibrio parahaemolyticus is a leading causative agent of seafood-borne gastroenteritis worldwide. Most clinical isolates from patients with diarrhoea possess two sets of genes for the type III secretion system (T3SS) on each chromosome (T3SS1 and T3SS2). T3SS is a protein secretion system that delivers effector proteins directly into eukaryotic cells. The injected effectors modify the normal cell functions by altering or disrupting the normal cell signalling pathways. Of the two sets of T3SS genes present in V.parahaemolyticus, T3SS2 is essential for enterotoxicity in several animal models. Recent studies have elucidated the biological activities of several T3SS2 effectors and their roles in virulence. This review focuses on the regulation of T3SS2 gene expression and T3SS2 effectors that specifically target the actin cytoskeleton.
AB - Vibrio parahaemolyticus is a leading causative agent of seafood-borne gastroenteritis worldwide. Most clinical isolates from patients with diarrhoea possess two sets of genes for the type III secretion system (T3SS) on each chromosome (T3SS1 and T3SS2). T3SS is a protein secretion system that delivers effector proteins directly into eukaryotic cells. The injected effectors modify the normal cell functions by altering or disrupting the normal cell signalling pathways. Of the two sets of T3SS genes present in V.parahaemolyticus, T3SS2 is essential for enterotoxicity in several animal models. Recent studies have elucidated the biological activities of several T3SS2 effectors and their roles in virulence. This review focuses on the regulation of T3SS2 gene expression and T3SS2 effectors that specifically target the actin cytoskeleton.
UR - http://www.scopus.com/inward/record.url?scp=84921602330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921602330&partnerID=8YFLogxK
U2 - 10.1111/cmi.12408
DO - 10.1111/cmi.12408
M3 - Article
VL - 17
SP - 183
EP - 190
JO - Cellular Microbiology
JF - Cellular Microbiology
SN - 1462-5814
IS - 2
ER -