Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton

Toshio Kodama, Hirotaka Hiyoshi, Ryu Okada, Shigeaki Matsuda, Kazuyoshi Goto, Tetsuya Iida

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Vibrio parahaemolyticus is a leading causative agent of seafood-borne gastroenteritis worldwide. Most clinical isolates from patients with diarrhoea possess two sets of genes for the type III secretion system (T3SS) on each chromosome (T3SS1 and T3SS2). T3SS is a protein secretion system that delivers effector proteins directly into eukaryotic cells. The injected effectors modify the normal cell functions by altering or disrupting the normal cell signalling pathways. Of the two sets of T3SS genes present in V.parahaemolyticus, T3SS2 is essential for enterotoxicity in several animal models. Recent studies have elucidated the biological activities of several T3SS2 effectors and their roles in virulence. This review focuses on the regulation of T3SS2 gene expression and T3SS2 effectors that specifically target the actin cytoskeleton.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalCellular Microbiology
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

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Vibrio parahaemolyticus
Actin Cytoskeleton
Gene Expression
Seafood
Gastroenteritis
Gene Expression Regulation
Eukaryotic Cells
Genes
Virulence
Diarrhea
Animal Models
Chromosomes
Proteins
Type III Secretion Systems
Protein Translocation Systems

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology
  • Medicine(all)

Cite this

Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton. / Kodama, Toshio; Hiyoshi, Hirotaka; Okada, Ryu; Matsuda, Shigeaki; Goto, Kazuyoshi; Iida, Tetsuya.

In: Cellular Microbiology, Vol. 17, No. 2, 01.02.2015, p. 183-190.

Research output: Contribution to journalArticle

Kodama, Toshio ; Hiyoshi, Hirotaka ; Okada, Ryu ; Matsuda, Shigeaki ; Goto, Kazuyoshi ; Iida, Tetsuya. / Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton. In: Cellular Microbiology. 2015 ; Vol. 17, No. 2. pp. 183-190.
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