Abstract
Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.
| Original language | English |
|---|---|
| Pages (from-to) | 153-160 |
| Number of pages | 8 |
| Journal | Seminars in Nephrology |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 1 2007 |
| Externally published | Yes |
Keywords
- HETE
- Protein kinase C
- decorin
- glucose excursion
- macrophages
- podocytes
- reactive oxygen species
- thrombospondin
- upstream stimulatory factor
ASJC Scopus subject areas
- Nephrology
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Zhu, Y., Usui, H. K., & Sharma, K. (2007). Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment. Seminars in Nephrology, 27(2), 153-160. https://doi.org/10.1016/j.semnephrol.2007.01.008