Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

Yanqing Zhu; Hitomi Kataoka Usui; Kumar Sharma

doi:10.1016/j.semnephrol.2007.01.008

Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

Yanqing Zhu, Hitomi Kataoka Usui, Kumar Sharma

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.

Original language	English
Pages (from-to)	153-160
Number of pages	8
Journal	Seminars in Nephrology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.semnephrol.2007.01.008
Publication status	Published - Mar 2007
Externally published	Yes

Keywords

HETE
Protein kinase C
decorin
glucose excursion
macrophages
podocytes
reactive oxygen species
thrombospondin
upstream stimulatory factor

ASJC Scopus subject areas

Nephrology

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10.1016/j.semnephrol.2007.01.008

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title = "Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment",

abstract = "Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.",

keywords = "HETE, Protein kinase C, decorin, glucose excursion, macrophages, podocytes, reactive oxygen species, thrombospondin, upstream stimulatory factor",

author = "Yanqing Zhu and Usui, {Hitomi Kataoka} and Kumar Sharma",

note = "Funding Information: Supported by the National Institutes of Health (R01DK053867-07, R01DK063017-04, U01DK076133-02 to K.S.), the American Diabetes Association, and the Juvenile Diabetes Research Foundation. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

month = mar,

doi = "10.1016/j.semnephrol.2007.01.008",

language = "English",

volume = "27",

pages = "153--160",

journal = "Seminars in Nephrology",

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T2 - Implications for Treatment

AU - Zhu, Yanqing

AU - Usui, Hitomi Kataoka

AU - Sharma, Kumar

N1 - Funding Information: Supported by the National Institutes of Health (R01DK053867-07, R01DK063017-04, U01DK076133-02 to K.S.), the American Diabetes Association, and the Juvenile Diabetes Research Foundation. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/3

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N2 - Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.

AB - Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.

KW - HETE

KW - Protein kinase C

KW - decorin

KW - glucose excursion

KW - macrophages

KW - podocytes

KW - reactive oxygen species

KW - thrombospondin

KW - upstream stimulatory factor

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Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

Abstract

Keywords

ASJC Scopus subject areas

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