Abstract
Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.
| Original language | English |
|---|---|
| Pages (from-to) | 153-160 |
| Number of pages | 8 |
| Journal | Seminars in Nephrology |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2007 |
| Externally published | Yes |
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Keywords
- decorin
- glucose excursion
- HETE
- macrophages
- podocytes
- Protein kinase C
- reactive oxygen species
- thrombospondin
- upstream stimulatory factor
ASJC Scopus subject areas
- Nephrology
Cite this
Regulation of Transforming Growth Factor β in Diabetic Nephropathy : Implications for Treatment. / Zhu, Yanqing; Kataoka, Hitomi; Sharma, Kumar.
In: Seminars in Nephrology, Vol. 27, No. 2, 03.2007, p. 153-160.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of Transforming Growth Factor β in Diabetic Nephropathy
T2 - Implications for Treatment
AU - Zhu, Yanqing
AU - Kataoka, Hitomi
AU - Sharma, Kumar
PY - 2007/3
Y1 - 2007/3
N2 - Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.
AB - Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.
KW - decorin
KW - glucose excursion
KW - HETE
KW - macrophages
KW - podocytes
KW - Protein kinase C
KW - reactive oxygen species
KW - thrombospondin
KW - upstream stimulatory factor
UR - http://www.scopus.com/inward/record.url?scp=34147159558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147159558&partnerID=8YFLogxK
U2 - 10.1016/j.semnephrol.2007.01.008
DO - 10.1016/j.semnephrol.2007.01.008
M3 - Article
C2 - 17418684
AN - SCOPUS:34147159558
VL - 27
SP - 153
EP - 160
JO - Seminars in Nephrology
JF - Seminars in Nephrology
SN - 0270-9295
IS - 2
ER -