Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

Yanqing Zhu, Hitomi Kataoka Usui, Kumar Sharma

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalSeminars in Nephrology
Volume27
Issue number2
DOIs
Publication statusPublished - Mar 1 2007

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Keywords

  • HETE
  • Protein kinase C
  • decorin
  • glucose excursion
  • macrophages
  • podocytes
  • reactive oxygen species
  • thrombospondin
  • upstream stimulatory factor

ASJC Scopus subject areas

  • Nephrology

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