Regulation of the ion-transporting mitochondrion-rich cell during adaptation of teleost fishes to different salinities

Tatsuya Sakamoto, Katsuhisa Uchida, Shigefumi Yokota

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88 Citations (Scopus)


The mitochondrion-rich cells (MRCs) in teleost gill and equivalent tissues are important osmo-regulatory sites in maintaining ionic balance. These cells express a variety of ion pumps, transporters, and channels, which play central roles in ionic regulation. Recently, two types of MRCs have been identified in euryhaline fishes: seawater (SW)-type MRCs extrude Na and Cl ions in SW conditions; freshwater (FW)-type MRCs take up at least Cl-. Long-term development/differentiation of the two types of MRCs during adaptation to different salinities appears to be regulated mainly by endocrine factors. Osmolality, Ca2+, neurotransmitters, and fast-acting hormones rapidly regulate the SW MRCs. Recent information is assembled in this review and suggests the functional plasticity of highly specialized MRCs.

Original languageEnglish
Pages (from-to)1163-1174
Number of pages12
JournalZoological science
Issue number9
Publication statusPublished - Dec 1 2001
Externally publishedYes



  • Adaptation
  • Chloride cell
  • Fish
  • Mitochondrion-rich cell
  • Osmoregulation

ASJC Scopus subject areas

  • Animal Science and Zoology

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