Regulation of opioid peptides on the release of Arginine vasotocin in the hen

Takeshi Sasaki, Kiyoshi Shimada, Noboru Saito

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Arginine vasotocin (AVT), an avian neurohypophysial hormone, is released during osmotic stimulation and oviposition. In the present study, the role of opioid peptides on AVT release was studied by examining the effects of an opioid agonist and antagonist on osmotic- and oviposition-induced secretion of AVT. The administration of hypertonic saline (1.5 M NACl) induced an increase in the plasma levels of AVT. The simultaneous administration of morphine, an opioid receptor agonist, inhibited the osmotically induced increase in plasma levels of AVT in a dose-dependent manner. On the other hand, the co-administration of morphine with naloxone, an opioid receptor antagonist, attenuated the inhibitory effect of morphine. Moreover, injection of naloxone alone enhanced the osmotically induced increase in plasma levels of AVT. However, the administration of morphine did not inhibit the oviposition-induced increase in plasma levels of AVT. These results suggest that osmotic-induced release of AVT may be under opioid regulation, while ovipositio-induced release of AVT may be controlled by a different mechanism. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalJournal of Experimental Zoology
Volume286
Issue number5
DOIs
Publication statusPublished - Apr 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology

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