Regulation of mitochondrial dynamics and neurodegenerative diseases

Xiao Jian Han, Kazuhito Tomizawa, Atsushi Fujimura, Iori Ohmori, Teiichi Nishiki, Masayuki Matsushita, Hideki Matsui

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusioa The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent studies, several large GTPases have been identified as key molecular factors in mitochondrial fission and fusion. Moreover, the posttranslational modifications of these large GTPases, including phosphorylation, ubiquitination and SUMOylation, have been shown to be involved in the regulation of mitochondrial dynamics. Neurons are particularly sensitive and vulnerable to any abnormalities in mitochondrial dynamics, due to their large energy demand and long extended processes. Emerging evidences have thus indicated a strong linkage between mitochondria and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. In this review, we will describe the regulation of mitochondrial dynamics and its role in neurodegenerative diseases.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalActa medica Okayama
Volume65
Issue number1
Publication statusPublished - Feb 22 2011

Keywords

  • Mitochondria
  • Neurodegeneration
  • Phosphorylation
  • SUMOylation
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Han, X. J., Tomizawa, K., Fujimura, A., Ohmori, I., Nishiki, T., Matsushita, M., & Matsui, H. (2011). Regulation of mitochondrial dynamics and neurodegenerative diseases. Acta medica Okayama, 65(1), 1-10.