Regulation of leg size and shape: Involvement of the Dachsous-fat signaling pathway

Tetsuya Bando, Taro Mito, Taro Nakamura, Hideyo Ohuchi, Sumihare Noji

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


How limb size and shape is regulated is a long-standing question in developmental and regeneration biology. Recently, the protocadherin Dachsous-Fat (Ds-Ft) signaling pathway has been found to be essential for wing development of the fly and leg regeneration of the cricket. The Ds-Ft signaling pathway is linked to the Warts-Hippo (Wts-Hpo) signaling pathway, leading to cell proliferation. Several lines of evidence have suggested that the Wts-Hpo signaling pathway is involved in the control of organ size, and that this pathway is regulated by Ds-Ft and Merlin-Expanded, which are linked to morphogens such as decapentaplegic/bone morphogenic protein, Wingless/Wnt, and epidermal growth factor. Here we review recent progress in elucidating mechanisms controlling leg size and shape in insects and vertebrates, focusing on the Ds-Ft signaling pathway. We also introduce a working model, Ds-Ft steepness model, to explain how steepness of the Ds-Ft gradient controls leg size along the proximodistal axis.

Original languageEnglish
Pages (from-to)1028-1041
Number of pages14
JournalDevelopmental Dynamics
Issue number5
Publication statusPublished - May 2011
Externally publishedYes


  • Dachsous-Fat signaling
  • Development
  • Gryllus bimaculatus
  • Hippo pathway
  • Limb
  • Merlin-Expanded
  • Regeneration
  • Wing imaginal disc

ASJC Scopus subject areas

  • Developmental Biology


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