Regulation of inflammation by members of the formyl-peptide receptor family

Keqiang Chen, Zhiyao Bao, Wanghua Gong, Peng Tang, Teizo Yoshimura, Ji Ming Wang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Inflammation is associated with a variety of diseases. The hallmark of inflammation is leukocyte infiltration at disease sites in response to pathogen- or damage-associated chemotactic molecular patterns (PAMPs and MAMPs), which are recognized by a superfamily of seven transmembrane, Gi-protein-coupled receptors (GPCRs) on cell surface. Chemotactic GPCRs are composed of two major subfamilies: the classical GPCRs and chemokine GPCRs. Formyl-peptide receptors (FPRs) belong to the classical chemotactic GPCR subfamily with unique properties that are increasingly appreciated for their expression on diverse host cell types and the capacity to interact with a plethora of chemotactic PAMPs and MAMPs. Three FPRs have been identified in human: FPR1-FPR3, with putative corresponding mouse counterparts. FPR expression was initially described in myeloid cells but subsequently in many non-hematopoietic cells including cancer cells. Accumulating evidence demonstrates that FPRs possess multiple functions in addition to controlling inflammation, and participate in the processes of many pathophysiologic conditions. They are not only critical mediators of myeloid cell trafficking, but are also implicated in tissue repair, angiogenesis and protection against inflammation-associated tumorigenesis. A series recent discoveries have greatly expanded the scope of FPRs in host defense which uncovered the essential participation of FPRs in step-wise trafficking of myeloid cells including neutrophils and dendritic cells (DCs) in host responses to bacterial infection, tissue injury and wound healing. Also of great interest is the FPRs are exploited by malignant cancer cells for their growth, invasion and metastasis. In this article, we review the current understanding of FPRs concerning their expression in a vast array of cell types, their involvement in guiding leukocyte trafficking in pathophysiological conditions, and their capacity to promote the differentiation of immune cells, their participation in tumor-associated inflammation and cancer progression. The close association of FPRs with human diseases and cancer indicates their potential as targets for the development of therapeutics.

Original languageEnglish
JournalJournal of Autoimmunity
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Formyl Peptide Receptor
Inflammation
Myeloid Cells
Neoplasms
Proteins
Leukocytes
Chemokine Receptors
Cell Surface Receptors
Bacterial Infections
Wound Healing
Dendritic Cells
Cell Differentiation
Carcinogenesis
Neutrophils
Neoplasm Metastasis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Regulation of inflammation by members of the formyl-peptide receptor family. / Chen, Keqiang; Bao, Zhiyao; Gong, Wanghua; Tang, Peng; Yoshimura, Teizo; Wang, Ji Ming.

In: Journal of Autoimmunity, 2017.

Research output: Contribution to journalArticle

Chen, Keqiang ; Bao, Zhiyao ; Gong, Wanghua ; Tang, Peng ; Yoshimura, Teizo ; Wang, Ji Ming. / Regulation of inflammation by members of the formyl-peptide receptor family. In: Journal of Autoimmunity. 2017.
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