Regulation of gonadotropin secretion by monitoring energy availability

Shuichi Matsuyama, Koji Kimura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nutrition is a principal environmental factor influencing fertility in animals. Energy deficit causes amenorrhea, delayed puberty, and suppression of copulatory behaviors by inhibiting gonadal activity. When gonadal activity is impaired by malnutrition, the signals originating from an undernourished state are ultimately conveyed to the gonadotropin-releasing hormone (GnRH) pulse generator, leading to suppressed secretion of GnRH and luteinizing hormone (LH). The mechanism responsible for energetic control of gonadotropin release is believed to involve metabolic signals, sensing mechanisms, and neuroendocrine pathways. The availabilities of blood-borne energy substrates such as glucose, fatty acids, and ketone bodies, which fluctuate in parallel with changes in nutritional status, act as metabolic signals that regulate the GnRH pulse generator activity and GnRH/LH release. As components of the specific sensing system, the ependymocytes lining the cerebroventricular wall in the lower brainstem integrate the information derived from metabolic signals to control gonadotropin release. One of the pathways responsible for the energetic control of gonadal activity consists of noradrenergic neurons from the solitary tract nucleus in the lower brainstem, projecting to the paraventricular nucleus of the hypothalamus. Further studies are needed to elucidate the mechanisms underlying energetic control of reproductive function.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalReproductive Medicine and Biology
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 1 2015
Externally publishedYes

Fingerprint

Gonadotropins
Gonadotropin-Releasing Hormone
Luteinizing Hormone
Brain Stem
Delayed Puberty
Adrenergic Neurons
Ketone Bodies
Solitary Nucleus
Paraventricular Hypothalamic Nucleus
Amenorrhea
Nutritional Status
Malnutrition
Hypothalamus
Fertility
Fatty Acids
Glucose

Keywords

  • Energy sensor
  • Gonadotropin
  • Metabolic signal
  • Neuroendocrine pathway
  • Nutrition

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

Cite this

Regulation of gonadotropin secretion by monitoring energy availability. / Matsuyama, Shuichi; Kimura, Koji.

In: Reproductive Medicine and Biology, Vol. 14, No. 2, 01.04.2015, p. 39-47.

Research output: Contribution to journalArticle

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