Regulation of fruiting body photomorphogenesis in Coprinopsis cinerea

Takashi Kamada, Hiroaki Sano, Takehito Nakazawa, Kiyoshi Nakahori

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

The agaricomycete (homobasidiomycete) Coprinopsis cinerea has been used as a model to study the molecular mechanism for photomorphogenesis. Molecular genetic analyses of mutants defective in fruiting body (mushroom) photomorphogenesis of C. cinerea identified two genes, dst1 and dst2. dst1 encodes a homolog of WC-1, a fungal blue-light photoreceptor first identified in Neurospora crassa, while dst2 encodes a novel protein with a putative flavin adenine dinucleotide (FAD)-binding-4 domain. In addition, reverse genetic analysis revealed that disruption of a C. cinerea gene encoding a WC-2 homolog, the partner of WC-1, causes the same blind phenotype. Searches on the genome data show that both WC-1 and WC-2 homologs are present in some agaricomycetes other than C. cinerea. Furthermore, in an agaricomycete, Lentinula edodes, it has been shown in vitro that the WC-1 and WC-2 homologs interact with each other. These findings suggest that the presumptive mechanism for blue-light sensing in agaricomycetes is fundamentally similar to that in Neurospora crassa, in which the WC-1/WC-2 complex plays a central role. Since the WC-1/WC-2 complex operates as a photoreceptor and a transcription factor, future studies will include identification of the targets of the WC-1/WC-2 complex that regulate photomorphogenesis in agaricomycetes. Another future challenge will be elucidation of the role of the newly identified photomorphogenetic protein, Dst2, in the blue-light-sensing mechanism.

Original languageEnglish
Pages (from-to)917-921
Number of pages5
JournalFungal Genetics and Biology
Volume47
Issue number11
DOIs
Publication statusPublished - Nov 1 2010

Keywords

  • Blue light
  • Coprinopsis cinerea
  • Coprinus cinereus
  • Dark stipe
  • Fruiting body
  • Mushroom
  • Oidia
  • Photomorphogenesis
  • Photoreceptor

ASJC Scopus subject areas

  • Microbiology
  • Genetics

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