Regulation of endochondral ossification by transcription factors

Riko Nishimura, Kenji Hata, Koichiro Ono, Katsuhiko Amano, Yoko Takigawa, Makoto Wakabayashi, Rikako Takashima, Toshiyuki Yoneda

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Endochondral ossification is very unique and complex biological event which is associated with skeletal development and tissue partnering. Genetic studies and gene-targeting approaches identified several transcription factors that play important roles in endochondral ossification. These transcription factors sequentially and harmoniously regulate each step of endochondral ossification, and consequently maintain the spatio-temporal control of the program. Importantly, these transcription factors form large protein complex to control chromatin remodeling, histone modification, transcription and splicing steps during endochondral ossification. It is also important to understand how these transcription factors regulate expression of their target genes. Biochemical and molecular cloning techniques largely contributed to identification of the components of the transcriptional complex and the target genes. Most recently, importance of endoplasmic reticulum (ER) stress in endochondral ossification has been reported. A transcription factor, BBF2H7, functions as an ER stress sensor in chondrocytes through regulation of appropriate secretion of chondrogenic matrices. We would like to discuss how the transcription factors regulate endochondral ossification.

Original languageEnglish
Pages (from-to)2657-2667
Number of pages11
JournalFrontiers in Bioscience
Volume17
Issue number7
DOIs
Publication statusPublished - Jun 1 2011
Externally publishedYes

Keywords

  • BMP
  • Chondrogenesis
  • Review
  • Runx2
  • Sox9
  • Wnt

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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