Regulation of cancer-related growth factor expression by artificial zinc-finger proteins.

Tomoaki Mori; Jun Sasaki; Yasuhiro Aoyama; Takashi Sera

doi:10.1093/nass/nrl145

Regulation of cancer-related growth factor expression by artificial zinc-finger proteins.

Tomoaki Mori, Jun Sasaki, Yasuhiro Aoyama, Takashi Sera

Research output: Contribution to journal › Article › peer-review

Abstract

One attractive approach to anticancer therapy is repression of expression of vascular endothelial growth factor (VEGF) gene, which is a potent target for prevention of tumor growth. To achieve this, artificial transcription factors (ATF) designed for VEGF gene regulation were fused to cell-penetrating peptides (CPPs). We demonstrated ATFs fused to CPPs, designated CPP-ATFs or designed regulatory proteins (DRPs), could penetrate into mammalian cells and transiently repress expression of a reporter gene, which was under control of the VEGF promoter/5'-UTR. We discuss gene-regulatory properties of CPP-ATFs in detail.

Original language	English
Pages (from-to)	291-292
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	50
DOIs	https://doi.org/10.1093/nass/nrl145
Publication status	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/nass/nrl145

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title = "Regulation of cancer-related growth factor expression by artificial zinc-finger proteins.",

abstract = "One attractive approach to anticancer therapy is repression of expression of vascular endothelial growth factor (VEGF) gene, which is a potent target for prevention of tumor growth. To achieve this, artificial transcription factors (ATF) designed for VEGF gene regulation were fused to cell-penetrating peptides (CPPs). We demonstrated ATFs fused to CPPs, designated CPP-ATFs or designed regulatory proteins (DRPs), could penetrate into mammalian cells and transiently repress expression of a reporter gene, which was under control of the VEGF promoter/5'-UTR. We discuss gene-regulatory properties of CPP-ATFs in detail.",

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AU - Aoyama, Yasuhiro

AU - Sera, Takashi

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AB - One attractive approach to anticancer therapy is repression of expression of vascular endothelial growth factor (VEGF) gene, which is a potent target for prevention of tumor growth. To achieve this, artificial transcription factors (ATF) designed for VEGF gene regulation were fused to cell-penetrating peptides (CPPs). We demonstrated ATFs fused to CPPs, designated CPP-ATFs or designed regulatory proteins (DRPs), could penetrate into mammalian cells and transiently repress expression of a reporter gene, which was under control of the VEGF promoter/5'-UTR. We discuss gene-regulatory properties of CPP-ATFs in detail.

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Regulation of cancer-related growth factor expression by artificial zinc-finger proteins.

Abstract

ASJC Scopus subject areas

UN SDGs

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