Regulation of actin dynamics by PI(4,5)P2 in cell migration and endocytosis

Yosuke Senju, Pekka Lappalainen

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

The actin cytoskeleton is indispensable for several cellular processes, including migration, morphogenesis, polarized growth, endocytosis, and phagocytosis. The organization and dynamics of the actin cytoskeleton in these processes are regulated by Rho family small GTPases and kinase-phosphatase pathways. Moreover, membrane phospholipids, especially the phosphatidylinositol phosphates have emerged as important regulators of actin dynamics. From these, PI(4,5)P2 is the most abundant at the plasma membrane, and directly regulates the activities and subcellular localizations of numerous actin-binding proteins. Here, we discuss recent studies demonstrating that actin-binding proteins interact with PI(4,5)P2-rich membranes through drastically different affinities and dynamics correlating with their roles in cytoskeletal dynamics. Moreover, by using mesenchymal cell migration and clathrin-mediated endocytosis as examples, we present a model for how interplay between PI(4,5)P2 and actin-binding proteins control the actin cytoskeleton in cells.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume56
DOIs
Publication statusPublished - Feb 2019
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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